A facile reduction of 2-aminopyrimidines with triethylsilane and trifluoroacetic acid

被引：24

作者：

Baskaran, S ^{[1
]}

Hanan, E ^{[1
]}

Byun, D ^{[1
]}

Shen, W ^{[1
]}

机构：

[1] Sunesis Pharmaceut, San Francisco, CA 94080 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 10期

关键词：

reduction; pyrimidine; triethylsilane; guanidine;

D O I：

10.1016/j.tetlet.2004.01.056

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Aminopyrimidines were facilely reduced to 2-amino-dihydro- or 2-amino-tetrahydropypryrimidines with triethylsilane and trifluroacetic acid in high yields. By controlling the equivalents of reducing reagents and temperature, selective reduction could also be achieved for some substrates. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：2107 / 2111

页数：5

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