Effects of Lactic Acid-Fermented Soymilk on Lipid Metabolism-Related Gene Expression in Rat Liver

被引：16

作者：

Kobayashi, Maki ^{[1
]}

Harada, Tomoko ^{[1
]}

Takagi, Naohiro ^{[1
]}

Tsuzuki, Kimiko ^{[2
]}

Sugawara, Makoto ^{[2
]}

Fukuda, Mitsuru ^{[1
]}

机构：

[1] Mukogawa Womens Univ, Sch Human Environm Sci, Dept Food Sci & Nutr, Nishinomiya, Hyogo 6638558, Japan

[2] Marusan Ai Co Ltd, Res Inst, Okazaki, Aichi 4442193, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2012年 / 76卷 / 01期

关键词：

fermented soymilk; lipid metabolism; DNA microarray; cytochrome p450 family 7 subfamily a polypeptide 1 (CYP7a1); isoflavone; SOY PROTEIN ISOLATE; SERUM-CHOLESTEROL; DIETARY-PROTEIN; PATHWAY; BINDING; PLASMA; METAANALYSIS; CONSUMPTION; GLUCOSIDES; MECHANISMS;

D O I：

10.1271/bbb.100354

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the effects of lactic acid fermentation of soymilk on the lipid profile and lipid metabolism-related gene expression in rat liver. Male Sprague-Dawley rats aged 7 weeks were fed a control diet (AIN-93), soymilk diet, or fermented soymilk diet for 1 week or 5 weeks. The hepatic triglyceride and cholesterol contents in the soymilk (SM) group and the fermented soymilk (FSM) group were significantly lower than those in the control group after 5 weeks, but these changes had not become apparent until after I week. The fatty acid synthesis-related genes were more markedly down-regulated after 1 week than after 5 weeks, whereas the cytochrome p450 family 7 subfamily a polypeptide 1 (CYP7a1) gene related to cholesterol catabolism was more markedly up-regulated after 5 weeks than after 1 week. This up-regulation was higher in the FSM group than in the SM group. It is assumed that the bioactive components produced by lactic acid fermentation induced the up-regulation of CYP7a1.

引用

页码：19 / 24

页数：6

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