Curvature factor and membrane solubilization, with particular reference to membrane rafts

被引：11

作者：

Mrowczynska, Lucyna ^{[2
]}

Salzer, Ulrich ^{[3
]}

Iglic, Ales ^{[4
]}

Hagerstrand, Henry ^{[1
]}

机构：

[1] Abo Akad Univ, Dept Biosci, FIN-20520 Turku, Finland

[2] Adam Mickiewicz Univ, Dept Cell Biol, PL-61614 Poznan, Poland

[3] Med Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria

[4] Fac Elect Engn, Biophys Lab, SI-1000 Ljubljana, Slovenia

来源：

CELL BIOLOGY INTERNATIONAL | 2011年 / 35卷 / 10期

关键词：

detergent-resistant membrane; membrane curvature; raft; solubilization; Triton X-100; DETERGENT-RESISTANT MEMBRANES; ERYTHROCYTES FOLLOWING TREATMENT; LIPID RAFTS; PLASMA-MEMBRANE; CELL-MEMBRANES; TRITON X-100; PHYSIOLOGICAL TEMPERATURE; SHAPE TRANSFORMATIONS; BIOLOGICAL-MEMBRANES; PROTEIN-COMPOSITION;

D O I：

10.1042/CBI20100786

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The composition of membrane rafts (cholesterol/sphingolipid-rich domains) cannot be fully deduced from the analysis of a detergent-resistant membrane fraction after solubilization in Triton X-100 at 4 degrees C. It is hypothesized that the membrane curvature-dependent lateral distribution of membrane components affects their solubilization. The stomatocytogenic, Triton X-100, cannot effectively solubilize membrane components, especially with regard to the outward membrane curvature.

引用

页码：991 / 995

页数：5

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