Association of small dense low-density lipoprotein with cardiovascular outcome in patients with coronary artery disease and diabetes: a prospective, observational cohort study

被引:43
作者
Jin, Jing-Lu [1 ]
Zhang, Hui-Wen [1 ]
Cao, Ye-Xuan [1 ]
Liu, Hui-Hui [1 ]
Hua, Qi [2 ]
Li, Yan-Fang [3 ]
Zhang, Yan [1 ]
Wu, Na-Qiong [1 ]
Zhu, Cheng-Gang [1 ]
Xu, Rui-Xia [1 ]
Gao, Ying [1 ]
Li, Xiao-Lin [1 ]
Cui, Chuan-Jue [1 ]
Liu, Geng [1 ]
Sun, Jing [1 ]
Dong, Qian [1 ]
Guo, Yuan-Lin [1 ]
Li, Jian-Jun [1 ]
机构
[1] Chinese Acad Med Sci, Fu Wai Hosp, Peking Union Med Coll, State Key Lab Cardiovasc Dis,Natl Ctr Cardiovasc, BeiLiShi Rd 167, Beijing 100037, Peoples R China
[2] Capital Med Univ, Xuanwu Hosp, Dept Cardiol, Beijing 100053, Peoples R China
[3] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China
关键词
sdLDL; MACEs; CAD; DM; HEART-DISEASE; CHOLESTEROL CONCENTRATIONS; LDL CHOLESTEROL; RISK; THERAPY; ATHEROSCLEROSIS; DYSLIPIDEMIA; SUBFRACTIONS; SEVERITY; ASSAY;
D O I
10.1186/s12933-020-01015-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Elevation in small dense low-density lipoprotein (sdLDL) is common in patients with diabetes mellitus (DM), which has already been reported to be associated with incidence of coronary artery disease (CAD). The aim of the present study was to investigate the prognostic value of plasma sdLDL level in patients with stable CAD and DM. Methods A total of 4148 consecutive patients with stable CAD were prospectively enrolled into the study and followed up for major cardiovascular events (MACEs) up to 8.5 years. Plasma sdLDL level was measured in each patient by a direct method using automated chemistry analyzer. The patients were subsequently divided into four groups by the quartiles of sdLDL and the association of sdLDL level with MACEs in different status of glucose metabolism [DM, Pre-DM, normal glycaemia regulation (NGR)] was evaluated. Results A total of 464 MACEs were documented. Both Kaplan-Meier analysis and Cox regression analysis indicated that the patients in quartile 4 but not quartile 2 or 3 of sdLDL level had significantly higher rate of MACEs than that in lowest quartile. When the prognostic value of high sdLDL was assessed in different glucose metabolism status, the results showed that the high sdLDL plus DM was associated with worse outcome after adjustment of confounding risk factors (hazard ratio: 1.83, 95% confident interval: 1.24-2.70, p < 0.05). However, no significant association was observed for high sdLDL plus Pre-DM or NGR. Conclusions The present study firstly indicated that elevated levels of plasma sdLDL were associated with increased risk of MACEs among DM patients with proven CAD, suggesting that sdLDL may be useful for CAD risk stratification in DM.
引用
收藏
页数:10
相关论文
共 50 条
  • [41] Predictive value of small dense low-density lipoprotein cholesterol for cardiovascular events in Chinese elder diabetes mellitus patients
    Xu, Li
    Chen, Xu
    Lu, Jingfen
    Xu, Yan
    Yang, Honglin
    Zhou, Xuewen
    Zhou, Jun
    Xu, Jianhong
    Shen, Hao
    DIABETOLOGY & METABOLIC SYNDROME, 2021, 13 (01)
  • [42] Changes in Small Dense Low-Density Lipoprotein Levels Following Acute Coronary Syndrome
    Emadzadeh, Mahdi Reza
    Alavi, Maryam-Sadat
    Soukhtanloo, Mohammad
    Mohammadpour, Toktam
    Rahsepar, Amir Ali
    Tavallaie, Shima
    Khojasteh, Roshanak
    Paydar, Roghayeh
    Amini, Maral
    Parizadeh, Seyyed Mohammad Reza
    Akhlaghi, Saeed
    Ghayour-Mobarhan, Majid
    Ferns, Gordon A.
    ANGIOLOGY, 2013, 64 (03) : 216 - 222
  • [43] Associations of small dense low-density lipoprotein and adiponectin with complications of type 2 diabetes
    Esteghamati, Alireza
    Asnafi, Solmaz
    Eslamian, Mohammad
    Noshad, Sina
    Nakhjavani, Manouchehr
    ENDOCRINE RESEARCH, 2015, 40 (01) : 14 - 19
  • [44] Serum low-density lipoprotein levels, statin use, and cognition in patients with coronary artery disease
    Rej, Soham
    Saleem, Mahwesh
    Herrmann, Nathan
    Stefatos, Anthi
    Rau, Allison
    Lanctot, Krista L.
    NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2016, 12 : 2913 - 2920
  • [45] Trajectory of low-density lipoprotein cholesterol in patients with chronic kidney disease and its association with cardiovascular disease
    Wang, Shih-Wei
    Li, Lung-Chih
    Fu, Chung-Ming
    Lee, Yueh-Ting
    Kuo, Hsiao-Ching
    Hsu, Chien-Ning
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, 9
  • [46] Oxidized Low-Density Lipoprotein Cholesterol and Coronary Artery Disease
    Indermuehle, Andreas
    Crake, Tom
    Meier, Pascal
    CARDIOLOGY, 2011, 119 (02) : 106 - 107
  • [47] Small-Dense Low-Density Lipoprotein Cholesterol: A Subclinical Marker for the Primary Prevention of Coronary Heart Disease
    Kokubo, Yoshihiro
    Watanabe, Makoto
    Higashiyama, Aya
    Honda-Kohmo, Kyoko
    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2020, 27 (07) : 641 - 643
  • [48] Evaluation of oxidized low-density lipoprotein in the coronary circulation of patients with coronary artery disease, and its association with percutaneous coronary intervention
    Ramadan, Mahmoud M.
    Kodama, Makoto
    Hirono, Satoru
    Okura, Yuji
    Mitsuma, Wataru
    Ito, Masahiro
    Aizawa, Yoshifusa
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2009, 134 (03) : E117 - E119
  • [49] Association of Low-Density Lipoprotein-Cholesterol and Its Small, Dense Phenotype with Six-Month Cardiovascular Morbidity
    Ibrahim, Sufyan
    Udupi, Anurupa
    Rebeiro, Cleeta
    Suryakanth, Varashree Bolar
    Kamath, Asha
    Shenoy, Revathi Panduranga
    REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2022, 11 (02): : 350 - 357
  • [50] Study on the value of small dense low-density lipoprotein in predicting cardiovascular and cerebrovascular events in the high-risk stroke population
    Shi, Hanlu
    Guo, Jianwei
    Xu, Ke
    Zhang, Fujie
    Zhou, Yonglie
    JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2022, 36 (04)