HPLC-ESI-MSn Identification and NMR Characterization of Glucosyloxybenzyl 2R-Benzylmalate Deriva-Tives from Arundina Graminifolia and Their Anti-Liver Fibrotic Effects In Vitro

被引：8

作者：

Liu, Qingqing ^{[1
]}

Sun, Feiyi ^{[1
]}

Deng, Yulin ^{[1
]}

Dai, Rongji ^{[1
]}

Lv, Fang ^{[1
]}

机构：

[1] Beijing Inst Technol, Sch Life Sci, Beijing Key Lab Separat & Anal Biomed & Pharmaceu, Beijing 100081, Peoples R China

来源：

MOLECULES | 2019年 / 24卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Arundina graminifolia; glucosyloxybenzyl; 2R-benzylmalates; MSn fragmentation pattern; anti-liver fibrotic effects; PHENOLIC-COMPOUNDS; DIPHENYLETHYLENES;

D O I：

10.3390/molecules24030525

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new glucosyloxybenzyl 2R-benzylmalate derivatives, named Arundinoside H (2), I (5), J (6), K (8) as well as four known compounds Arundinoside D (1), G (3), F (4), E (7) were isolated and characterized by a combination of chemical and spectroscopic methods, including HR-ESI-MS, 1D and 2D NMR experiments. Besides, 24 unreported compounds were inferred from ESI-MSn data. The anti-liver fibrotic activities of the isolates were determined as proliferation inhibition of lipopolysaccharide (LPS)-induced activation of rat hepatic stellate cells (HSC-T6). The result suggested Arundinosides D, H, F, I and K showed moderate inhibitory effects in vitro.

引用

页数：15