DNA sequencing by nanopores: advances and challenges

被引：37

作者：

Agah, Shaghayegh ^{[1
]}

Zheng, Ming ^{[2
]}

Pasquali, Matteo ^{[1
,3
,4
]}

Kolomeisky, Anatoly B. ^{[1
,3
,5
]}

机构：

[1] Rice Univ, Dept Chem & Biomol Engn, Houston, TX 77005 USA

[2] NIST, Gaithersburg, MD 20899 USA

[3] Rice Univ, Dept Chem, Houston, TX 77005 USA

[4] Rice Univ, Smalley Inst Nanoscale Sci & Technol, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA

[5] Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA

来源：

JOURNAL OF PHYSICS D-APPLIED PHYSICS | 2016年 / 49卷 / 41期

基金：

美国国家科学基金会;

关键词：

DNA sequencing; translocation; biological nanopores; artificial nanopores; carbon nanotubes; fluorescence; WALLED CARBON NANOTUBES; SOLID-STATE; OPTICAL-DETECTION; ALPHA-HEMOLYSIN; NUCLEIC-ACIDS; STRANDED-DNA; GRAPHENE; PROTEIN; TRANSLOCATION; MINION;

D O I：

10.1088/0022-3727/49/41/413001

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Developing inexpensive and simple DNA sequencing methods capable of detecting entire genomes in short periods of time could revolutionize the world of medicine and technology. It will also lead to major advances in our understanding of fundamental biological processes. It has been shown that nanopores have the ability of single-molecule sensing of various biological molecules rapidly and at a low cost. This has stimulated significant experimental efforts in developing DNA sequencing techniques by utilizing biological and artificial nanopores. In this review, we discuss recent progress in the nanopore sequencing field with a focus on the nature of nanopores and on sensing mechanisms during the translocation. Current challenges and alternative methods are also discussed.

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