Hijacked in cancer: the KMT2 (MLL) family of methyltransferases

被引：472

作者：

Rao, Rajesh C. ^{[1
,2
]}

Dou, Yali ^{[1
,3
]}

机构：

[1] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Ophthalmol & Visual Sci, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA

来源：

NATURE REVIEWS CANCER | 2015年 / 15卷 / 06期

基金：

美国国家卫生研究院;

关键词：

LYSINE; 4; METHYLATION; HISTONE H3; TUMOR-SUPPRESSOR; STRUCTURAL BASIS; FUSION GENE; P-TEFB; TRANSCRIPTIONAL ELONGATION; CHROMATIN MODIFICATIONS; MOLECULAR RECOGNITION; THERAPEUTIC TARGET;

D O I：

10.1038/nrc3929

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Histone-lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on the histone H3 tail at important regulatory regions in the genome and thereby impart crucial functions through modulating chromatin structures and DNA accessibility. Although the human KMT2 family was initially named the mixed-lineage leukaemia (MLL) family, owing to the role of the first-found member KMT2A in this disease, recent exome-sequencing studies revealed KMT2 genes to be among the most frequently mutated genes in many types of human cancers. Efforts to integrate the molecular mechanisms of KMT2 with its roles in tumorigenesis have led to the development of first-generation inhibitors of KMT2 function, which could become novel cancer therapies.

引用

页码：334 / 346

页数：13

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