Effects of Expression of Transcriptional Factor AP-1 FOSL1 Gene on Psoriatic Process

被引：17

作者：

Sobolev, V. V. ^{[2
]}

Zolotorenko, A. D. ^{[2
]}

Soboleva, A. G. ^{[2
]}

Elkin, A. M. ^{[1
]}

Il'ina, S. A. ^{[1
]}

Serov, D. N. ^{[3
]}

Potekaev, N. N. ^{[3
]}

Tkachenko, S. B. ^{[3
]}

Minnibaev, M. T. ^{[3
]}

Piruzyan, A. L. ^{[1
]}

机构：

[1] Russian Acad Sci, Ctr Theoret Problems Phys & Chem Pharmacol, Moscow, Russia

[2] Russian Acad Sci, NI Vavilov Inst Gen Genet, Moscow, Russia

[3] IM Sechenov Moscow Med Acad, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2011年 / 150卷 / 05期

关键词：

psoriasis; gene expression; real time polymerase chain reaction; FOSL1; SQUAMOUS-CELL CARCINOMA; BINDING-ACTIVITY; FRA-1; OVEREXPRESSION; REQUIRES; SKIN;

D O I：

10.1007/s10517-011-1208-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We performed quantitative analysis of FOSL1 gene expression in lesional psoriatic skin. The expression of this gene in lesional psoriatic skin was significantly increased compared to that in unaffected areas. Enhanced FOSL1 expression significantly correlated with high psoriasis area and severity index (PASI). High level of FOSL1 gene expression was proposed to be a marker of pathological process activity in psoriasis.

引用

页码：632 / 634

页数：3

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