On the Adaptive Partition Approach to the Detection of Multiple Change-Points

被引:4
作者
Lai, Yinglei [1 ,2 ]
机构
[1] George Washington Univ, Dept Stat, Washington, DC 20052 USA
[2] George Washington Univ, Ctr Biostat, Washington, DC USA
基金
美国国家卫生研究院;
关键词
CIRCULAR BINARY SEGMENTATION; COPY-NUMBER; ARRAY; REGRESSION;
D O I
10.1371/journal.pone.0019754
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
With an adaptive partition procedure, we can partition a "time course'' into consecutive non-overlapped intervals such that the population means/proportions of the observations in two adjacent intervals are significantly different at a given level alpha(C). However, the widely used recursive combination or partition procedures do not guarantee a global optimization. We propose a modified dynamic programming algorithm to achieve a global optimization. Our method can provide consistent estimation results. In a comprehensive simulation study, our method shows an improved performance when it is compared to the recursive combination/partition procedures. In practice, alpha(C) can be determined based on a cross-validation procedure. As an application, we consider the well-known Pima Indian Diabetes data. We explore the relationship among the diabetes risk and several important variables including the plasma glucose concentration, body mass index and age.
引用
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页数:15
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