Association of polymorphisms near the FOXC2 gene with the risk of varicose veins in ethnic Russians

被引：2

作者：

Shadrina, Alexandra S. ^{[1
,2
]}

Smetanina, Mariya A. ^{[1
]}

Sokolova, Ekaterina A. ^{[1
,2
]}

Sevost'ianova, Kseniya S. ^{[1
]}

Shevela, Andrey I. ^{[1
]}

Demekhova, Marina Y. ^{[3
]}

Shonov, Oleg A. ^{[3
]}

Ilyukhin, Evgenii A. ^{[3
]}

Voronina, Elena N. ^{[1
,2
]}

Zolotukhin, Igor A. ^{[4
]}

Kirienko, Alexander I. ^{[4
]}

Filipenko, Maxim L. ^{[1
,2
,5
]}

机构：

[1] Inst Chem Biol & Fundamental Med, Novosibirsk, Russia

[2] Novosibirsk State Univ, Novosibirsk, Russia

[3] Private Surg Ctr Medalp, St Petersburg, Russia

[4] Pirogov Russian Natl Res Med Univ, Moscow, Russia

[5] Kazan Fed Univ, Kazan, Russia

来源：

PHLEBOLOGY | 2016年 / 31卷 / 09期

基金：

俄罗斯科学基金会;

关键词：

Varicose veins; FOXC2; single nucleotide polymorphism; association; Russians; LYMPHEDEMA-DISTICHIASIS SYNDROME; FORKHEAD TRANSCRIPTION FACTORS; CHRONIC VENOUS INSUFFICIENCY; ENDOTHELIAL-CELLS; MUTATIONS; EXPRESSION; FAMILY; POPULATION; REGULATOR; DISEASE;

D O I：

10.1177/0268355515607404

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Objective To investigate the association of polymorphisms located near the FOXC2 gene with the risk of varicose veins in ethnic Russians. Methods Allele, genotype, and haplotype frequencies were determined in the sample of 474 patients with primary varicose veins and in the control group of 478 individuals without a history of chronic venous disease. Results Polymorphisms rs7189489, rs4633732, and rs1035550 showed the association with the increased risk of varicose veins, but none of the observed associations remained significant after correction for multiple testing. Haplotype analysis revealed the association of haplotype rs7189489 C-rs4633732 T-rs34221221 C-rs1035550 C-rs34152738 T-rs12711457 G with the increased risk of varicose veins (OR=2.67, P=0.01). Conclusions Our results provide evidence that the studied polymorphisms do not play a major role in susceptibility to varicose veins development in the Russian population.

引用

页码：640 / 648

页数：9

共 43 条

[1] Effect of Family History on the Incidence of Varicose Veins: A Population-Based Follow-Up Study in Finland [J].

Ahti, Tiina M. ;

Makivaara, Liisa A. ;

Luukkaala, Tiina ;

Hakama, Matti ;

Laurikka, Jari O. .

ANGIOLOGY, 2009, 60 (04) :487-491

[2] FOXC2 truncating mutation in distichiasis, lymphedema, and cleft palate [J].

Bahuau, M ;

Houdayer, C ;

Tredano, M ;

Soupre, V ;

Couderc, R ;

Vazquez, MP .

CLINICAL GENETICS, 2002, 62 (06) :470-473

[3] The epidemiology of chronic venous insufficiency and varicose veins [J].

Beebe-Dimmer, JL ;

Pfeifer, JR ;

Engle, JS ;

Schottenfeld, D .

ANNALS OF EPIDEMIOLOGY, 2005, 15 (03) :175-184

[4] Analysis of lymphoedema-distichiasis families for FOXC2 mutations reveals small insertions and deletions throughout the gene [J].

Bell, R ;

Brice, G ;

Child, AH ;

Murday, VA ;

Mansour, S ;

Sandy, CJ ;

Collin, JRO ;

Brady, AF ;

Callen, DF ;

Burnand, K ;

Mortimer, P ;

Jeffery, S .

HUMAN GENETICS, 2001, 108 (06) :546-551

[5] Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24 [J].

Brice, G ;

Mansour, S ;

Bell, R ;

Collin, JR ;

Child, AH ;

Brady, AF ;

Sarfarazi, M ;

Burnand, KG ;

Jeffery, S ;

Mortimer, P ;

Murday, VA .

JOURNAL OF MEDICAL GENETICS, 2002, 39 (07) :478-483

[6] Heritability of venous function in humans [J].

Brinsuk, M ;

Tank, J ;

Luft, FC ;

Busjahn, A ;

Jordan, J .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (01) :207-211

[7] Role of the FOXC2-512C>T polymorphism in type 2 diabetes:: possible association with the dysmetabolic syndrome [J].

Carlsson, E ;

Groop, L ;

Ridderstråle, M .

INTERNATIONAL JOURNAL OF OBESITY, 2005, 29 (03) :268-274

[8] IMPORTANCE OF THE FAMILIAL FACTOR IN VARICOSE DISEASE - CLINICAL-STUDY OF 134 FAMILIES [J].

CORNUTHENARD, A ;

BOIVIN, P ;

BAUD, JM ;

DEVINCENZI, I ;

CARPENTIER, PH ;

AIDANE, P ;

BOHBOT, S ;

BONNEU, MM ;

BOUILLY, P ;

BRAMI, C ;

CHAUVEL, T ;

COPPE, G ;

DANIEL, CR ;

DAVINROY, M ;

DEFROYENNE, T ;

DECAMPSLECHEVOIR, J ;

DESHOGUES, B ;

DUPINGIROD, S ;

ELGRISHI, I ;

FLABEAU, C ;

GARDE, C ;

LEFORT, C ;

MARZIN, L ;

MEICLER, P ;

VANHOA, JFP ;

SCHADECK, M ;

SOBIAK, S ;

SUSSMAN, H ;

TARDY, G ;

TAVEAU, JF ;

TUOT, D ;

VIN, F .

JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY, 1994, 20 (05) :318-326

[9] Chronic venous disease in an ethnically diverse population - The San Diego population study [J].

Criqui, MH ;

Jamosmos, M ;

Fronek, A ;

Denenberg, JO ;

Langer, RD ;

Bergan, J ;

Golomb, BA .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2003, 158 (05) :448-456

[10] Risk factors for chronic venous disease: The San Diego population study [J].

Criqui, Michael H. ;

Denenberg, Julie O. ;

Bergan, John ;

Langer, Robert D. ;

Fronek, Arnost .

JOURNAL OF VASCULAR SURGERY, 2007, 46 (02) :331-337

← 1 2 3 4 5 →