Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

被引：2954

作者：

Blanco-Melo, Daniel ^{[1
,2
]}

Nilsson-Payant, Benjamin E. ^{[1
,2
]}

Liu, Wen-Chun ^{[1
,3
]}

Uhl, Skyler ^{[1
,2
]}

Hoagland, Daisy ^{[1
,2
]}

Moller, Rasmus ^{[1
,2
]}

Jordan, Tristan X. ^{[1
,2
]}

Oishi, Kohei ^{[1
,2
]}

Panis, Maryline ^{[1
,2
]}

Sachs, David ^{[4
]}

Wang, Taia T. ^{[5
,6
,7
]}

Schwartz, Robert E. ^{[8
]}

Lim, Jean K. ^{[1
]}

Albrecht, Randy A. ^{[1
,3
]}

tenOever, Benjamin R. ^{[1
,2
,3
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Virus Engn Ctr Therapeut & Res, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA

[5] Stanford Univ, Dept Med, Sch Med, Div Infect Dis, Stanford, CA 94305 USA

[6] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

[7] Chan Zuckerberg Biohub, San Francisco, CA USA

[8] Weill Cornell Med, Div Gastroenterol & Hepatol, Dept Med, New York, NY 10065 USA

来源：

CELL | 2020年 / 181卷 / 05期

基金：

美国国家卫生研究院;

关键词：

INTERFERON; CORONAVIRUS; SARS; TRANSMISSION; PATHOGENESIS; INFECTION; PROTEIN; CELLS;

D O I：

10.1016/j.cell.2020.04.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 compared with other respiratory viruses. Cell and animal models of SARS-CoV-2 infection, in addition to transcriptional and serum profiling of COVID-19 patients, consistently revealed a unique and inappropriate inflammatory response. This response is defined by low levels of type I and III interferons juxtaposed to elevated chemokines and high expression of IL-6. Wepropose that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.

引用

页码：1036 / +

页数：19

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