Update on the epidemiology of primary biliary cirrhosis

被引:6
作者
Chuang, Nelson [2 ]
Gross, Rebekah G. [3 ]
Odin, Joseph A. [1 ]
机构
[1] Mt Sinai Sch Med, Dept Med Liver Dis, Recanati Miller Transplantat Inst, New York, NY 10029 USA
[2] Robert Wood Johnson Sch Med, New Brunswick, NJ USA
[3] Weill Cornell Med Coll, New York, NY USA
关键词
environment; epidemiology; genetics; primary biliary cirrhosis; risk factors; ANTIMITOCHONDRIAL ANTIBODIES; RISK-FACTORS; NATURAL-HISTORY; PYRUVATE-DEHYDROGENASE; INCREASED PREVALENCE; DEFINED POPULATION; UNITED-KINGDOM; LIVER-DISEASE; FOLLOW-UP; ASSOCIATION;
D O I
10.1586/EGH.11.66
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The epidemiology of primary biliary cirrhosis was described as early as the 1970s, yet decades later the true frequency of this disease and its associated risk factors are still in question. There has been a wealth of data documenting the various incidence and prevalence rates across the world, demonstrating potential risk factors inherent to geographic differences. Studies that follow primary biliary cirrhosis in a set population over time have offered the most reliable picture of disease frequency. Analysis of clustering effects through region and time has offered valuable information on the complexity of the disease development. Improved epidemiologic surveillance of primary biliary cirrhosis around the world will be necessary to provide definitive evidence on the phenomenon of clustering and its associations with proposed risk factors in the literature.
引用
收藏
页码:583 / 590
页数:8
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