Urinary exosomes: Potential biomarkers for diabetic nephropathy

被引：39

作者：

Sinha, Nisha ^{[1
,2
]}

Kumar, Vivek ^{[2
]}

Puri, Veena ^{[3
]}

Nada, Ritambhra ^{[4
]}

Rastogi, Ashu ^{[5
]}

Jha, Vivekanand ^{[6
,7
]}

Puri, Sanjeev ^{[8
]}

机构：

[1] Punjab Univ, Ctr Stem Cell & Tissue Engn & Excellence Biomed S, Chandigarh, India

[2] Post Grad Inst Med Educ & Res, Dept Nephrol, Chandigarh, India

[3] Punjab Univ, Ctr Syst Biol & Bioinformat, Chandigarh, India

[4] Post Grad Inst Med Educ & Res, Dept Histopathol, Chandigarh, India

[5] Post Grad Inst Med Educ & Res, Dept Endocrinol & Metab, Chandigarh, India

[6] Univ Oxford, UNSW, India George Inst Global Hlth, George Inst Global Hlth, Oxford, England

[7] Manipal Acad Higher Educ, Manipal, India

[8] Punjab Univ, Univ Inst Engn & Technol UIET, Dept Biotechnol, Chandigarh, India

来源：

NEPHROLOGY | 2020年 / 25卷 / 12期

关键词：

biomarker; diabetic nephropathy; exosomes; microRNA; ADIPOSE-TISSUE; DIAGNOSIS; PROTEIN; IDENTIFICATION; PROTEOMICS; MICRORNAS; MELLITUS; CELLS; RISK;

D O I：

10.1111/nep.13720

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic nephropathy is the most common diabetic complication culminating often into end-stage renal disease. Classically, it is defined by the presence of albuminuria which has limited ability to be detected at early stages but deterioration in kidney function generally precedes albuminuria. This necessitates the development of newer diagnostic assays for diabetic nephropathy to determine the progression of the disease. Kidney associated diseases with non-albuminuria further complicates a timely diagnosis and thus demands an early biomarker. Urinary exosomes, the nanovesicular entities are released by every epithelial cells of the nephron. Their protein or molecular cargo varies in the diseased state which may provide the pathophysiology of the kidney associated diseases. This drives them to be exploited as non-invasive biomarker. This review thus integrates the recent findings on the significance of the urinary exosomes as diagnostic biomarker in kidney-associated diseases, primarily in diabetic nephropathy.

引用

页码：881 / 887

页数：7

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