Adipocytes;
adipose tissue;
gene expression;
inflammation;
protein arrays;
ADIPOSE-TISSUE;
INSULIN-RESISTANCE;
HUMAN ADIPOCYTES;
GENE-EXPRESSION;
OBESITY;
INFLAMMATION;
SECRETION;
DIFFERENTIATION;
ADIPOGENESIS;
DYSFUNCTION;
D O I:
10.3109/13813455.2016.1156706
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The effect of IL-1 beta on cytokine and chemokine production by human preadipocytes has been examined. Preadipocytes were incubated with IL-1 beta, and cytokine and chemokine release was measured at 24 h by protein arrays, while the expression of cytokine/chemokine genes was assessed by qPCR at 4 and 24 h. IL-1 beta stimulated the secretion of multiple cytokines/chemokines, including IL-6, IL-8, IL-10, IL-13, MCP-4, TNF alpha and IP-10. IL-10 was not released by un-stimulated preadipocytes, while IL-6 exhibited the greatest response to IL-1 beta (453-fold increase). IL-16 and IL-12p40 did not respond to IL-1 beta. qPCR demonstrated that IL-1 beta markedly stimulated CCL3, CSF3 and CXCL10 expression at 4 h (>900-fold mRNA increase). A time-course indicated that while CCL13 (encoding MCP-4) exhibited minimal basal expression in preadipocytes, expression increased progressively following differentiation. Human preadipocytes are highly sensitive to IL-1 beta, the cytokine stimulating a major inflammatory response in these cells similar to that in mature adipocytes.
机构:
King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia
King Saud Univ, Coll Sci, Cent Lab, Riyadh 11451, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Hop Archet, CNRS, LP2M, FRE3472, Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Ciucci, Thomas
Rousseau, Deborah
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Fac Med Nice, INSERM, Equipe Complicat Hepat Obesite, U1065, F-06034 Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Rousseau, Deborah
Bourlier, Virginie
论文数: 0引用数: 0
h-index: 0
机构:
Fac Med Toulouse, INSERM, Inst Malad Metab & Cardiovasc, U1048, F-31073 Toulouse, France
Univ Paul Sabatier Toulouse III, Toulouse, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Bourlier, Virginie
Duffaut, Carine
论文数: 0引用数: 0
h-index: 0
机构:
Fac Med Toulouse, INSERM, Inst Malad Metab & Cardiovasc, U1048, F-31073 Toulouse, France
Univ Paul Sabatier Toulouse III, Toulouse, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Duffaut, Carine
Bonnafous, Stephanie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Fac Med Nice, INSERM, Equipe Complicat Hepat Obesite, U1065, F-06034 Nice, France
CHU Nice, Hop Archet, Dept Digestif, Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Bonnafous, Stephanie
论文数: 引用数:
h-index:
机构:
Blin-Wakkach, Claudine
Anty, Rodolphe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Fac Med Nice, INSERM, Equipe Complicat Hepat Obesite, U1065, F-06034 Nice, France
CHU Nice, Hop Archet, Dept Digestif, Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Anty, Rodolphe
Iannelli, Antonio
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Fac Med Nice, INSERM, Equipe Complicat Hepat Obesite, U1065, F-06034 Nice, France
CHU Nice, Hop Archet, Dept Digestif, Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Iannelli, Antonio
Gugenheim, Jean
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Fac Med Nice, INSERM, Equipe Complicat Hepat Obesite, U1065, F-06034 Nice, France
CHU Nice, Hop Archet, Dept Digestif, Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Gugenheim, Jean
论文数: 引用数:
h-index:
机构:
Tran, Albert
Bouloumie, Anne
论文数: 0引用数: 0
h-index: 0
机构:
Fac Med Toulouse, INSERM, Inst Malad Metab & Cardiovasc, U1048, F-31073 Toulouse, France
Univ Paul Sabatier Toulouse III, Toulouse, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Bouloumie, Anne
Gual, Philippe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Fac Med Nice, INSERM, Equipe Complicat Hepat Obesite, U1065, F-06034 Nice, France
CHU Nice, Hop Archet, Dept Digestif, Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Gual, Philippe
Wakkach, Abdelilah
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Hop Archet, CNRS, LP2M, FRE3472, Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
机构:
Univ Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Univ Paris 05, UMR S 872, F-75006 Paris, FranceUniv Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Keophiphath, Mayoura
Achard, Vincent
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Univ Paris 05, UMR S 872, F-75006 Paris, FranceUniv Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Achard, Vincent
Henegar, Corneliu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Univ Paris 05, UMR S 872, F-75006 Paris, FranceUniv Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Henegar, Corneliu
Rouault, Christine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Univ Paris 05, UMR S 872, F-75006 Paris, FranceUniv Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Rouault, Christine
Clement, Karine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Univ Paris 05, UMR S 872, F-75006 Paris, France
Hop La Pitie Salpetriere, Assistance Publ Hop Paris, Endocrinol & Nutr Dept, F-75013 Paris, FranceUniv Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Clement, Karine
Lacasa, Daniele
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Univ Paris 05, UMR S 872, F-75006 Paris, FranceUniv Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
机构:
King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia
King Saud Univ, Coll Sci, Cent Lab, Riyadh 11451, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Hop Archet, CNRS, LP2M, FRE3472, Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Ciucci, Thomas
Rousseau, Deborah
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Fac Med Nice, INSERM, Equipe Complicat Hepat Obesite, U1065, F-06034 Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Rousseau, Deborah
Bourlier, Virginie
论文数: 0引用数: 0
h-index: 0
机构:
Fac Med Toulouse, INSERM, Inst Malad Metab & Cardiovasc, U1048, F-31073 Toulouse, France
Univ Paul Sabatier Toulouse III, Toulouse, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Bourlier, Virginie
Duffaut, Carine
论文数: 0引用数: 0
h-index: 0
机构:
Fac Med Toulouse, INSERM, Inst Malad Metab & Cardiovasc, U1048, F-31073 Toulouse, France
Univ Paul Sabatier Toulouse III, Toulouse, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Duffaut, Carine
Bonnafous, Stephanie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Fac Med Nice, INSERM, Equipe Complicat Hepat Obesite, U1065, F-06034 Nice, France
CHU Nice, Hop Archet, Dept Digestif, Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Bonnafous, Stephanie
论文数: 引用数:
h-index:
机构:
Blin-Wakkach, Claudine
Anty, Rodolphe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Fac Med Nice, INSERM, Equipe Complicat Hepat Obesite, U1065, F-06034 Nice, France
CHU Nice, Hop Archet, Dept Digestif, Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Anty, Rodolphe
Iannelli, Antonio
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Fac Med Nice, INSERM, Equipe Complicat Hepat Obesite, U1065, F-06034 Nice, France
CHU Nice, Hop Archet, Dept Digestif, Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Iannelli, Antonio
Gugenheim, Jean
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Fac Med Nice, INSERM, Equipe Complicat Hepat Obesite, U1065, F-06034 Nice, France
CHU Nice, Hop Archet, Dept Digestif, Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Gugenheim, Jean
论文数: 引用数:
h-index:
机构:
Tran, Albert
Bouloumie, Anne
论文数: 0引用数: 0
h-index: 0
机构:
Fac Med Toulouse, INSERM, Inst Malad Metab & Cardiovasc, U1048, F-31073 Toulouse, France
Univ Paul Sabatier Toulouse III, Toulouse, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Bouloumie, Anne
Gual, Philippe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Fac Med Nice, INSERM, Equipe Complicat Hepat Obesite, U1065, F-06034 Nice, France
CHU Nice, Hop Archet, Dept Digestif, Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
Gual, Philippe
Wakkach, Abdelilah
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Fac Med, Nice, France
Hop Archet, CNRS, LP2M, FRE3472, Nice, FranceUniv Nice Sophia Antipolis, Fac Med, Nice, France
机构:
Univ Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Univ Paris 05, UMR S 872, F-75006 Paris, FranceUniv Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Keophiphath, Mayoura
Achard, Vincent
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Univ Paris 05, UMR S 872, F-75006 Paris, FranceUniv Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Achard, Vincent
Henegar, Corneliu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Univ Paris 05, UMR S 872, F-75006 Paris, FranceUniv Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Henegar, Corneliu
Rouault, Christine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Univ Paris 05, UMR S 872, F-75006 Paris, FranceUniv Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Rouault, Christine
Clement, Karine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Univ Paris 05, UMR S 872, F-75006 Paris, France
Hop La Pitie Salpetriere, Assistance Publ Hop Paris, Endocrinol & Nutr Dept, F-75013 Paris, FranceUniv Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Clement, Karine
Lacasa, Daniele
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France
Univ Paris 05, UMR S 872, F-75006 Paris, FranceUniv Paris 06, INSERM, U872, Ctr Rech Cordeliers, F-75005 Paris, France