Rapid Access to Chroman-3-ones through Gold-Catalyzed Oxidation of Propargyl Aryl Ethers

被引：130
作者：
Wang, Yanzhao [1 ]
Ji, Kegong [1 ]
Lan, Sylvester [1 ]
Zhang, Liming [1 ]
机构：
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 08期
关键词：
carbenes; gold; heterocycles; homogeneous catalysis; oxidation; ALPHA-DIAZO KETONES; EFFICIENT SYNTHESIS; PHOSPHINE; 1,5-ENYNES; COMPLEXES; ALKYNES;
D O I：
10.1002/anie.201107561
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The two-step: Chroman-3-ones are important intermediates for organic synthesis and medicinal chemistry. However, their syntheses require multiple steps and are not efficient. By using gold-catalyzed alkyne oxidation, this versatile heterocycle can be prepared in only two steps from readily available phenols and with mostly high efficiencies (see scheme). © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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收藏
页码：1915 / 1918
页数：4
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