Increasing Effect of an Oral Intake of L-Hydroxyproline on the Soluble Collagen Content of Skin and Collagen Fragments in Rat Serum

被引：11

作者：

Aoki, Mami ^{[1
]}

Suto, Kouzou ^{[2
]}

Komatsu, Miho ^{[1
]}

Kamimura, Ayako ^{[1
]}

Morishita, Koji ^{[1
]}

Yamasaki, Motoo ^{[3
]}

Takao, Toshifumi ^{[2
]}

机构：

[1] KYOWA HAKKO BIO CO LTD, Healthcare Prod Dev Ctr, Tsukuba, Ibaraki 3050841, Japan

[2] Osaka Univ, Inst Prot Res, Lab Prot Profiling & Funct Prote, Suita, Osaka 5650871, Japan

[3] Kyowa Hakko Kirin Co Ltd, Machida, Tokyo 1940023, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2012年 / 76卷 / 06期

关键词：

oral intake; L-hydroxyproline; collagen; DEGRADATION; AGE;

D O I：

10.1271/bbb.120058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the effects of oral L-hydroxyproline (Hyp) on collagen in the body. After 2 weeks' administration of Hyp (0.5 or 1 g/kg) to F344 male rats, the soluble collagen content of the skin had increased, and the serum concentration of collagen peptides was correlated with the skin content of soluble collagen. This result suggests that oral Hyp augmented collagen metabolism.

引用

页码：1242 / 1244

页数：3

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