Improvement of flow and bulk density of pharmaceutical powders using surface modification

被引:138
作者
Jallo, Laila J. [1 ]
Ghoroi, Chinmay [1 ]
Gurumurthy, Lakxmi [1 ]
Patel, Utsav [1 ]
Dave, Rajesh N. [1 ]
机构
[1] New Jersey Inst Technol, New Jersey Ctr Engn Particulates, Newark, NJ 07102 USA
基金
美国国家科学基金会;
关键词
Dry coating; Design of experiment; Flow properties; Pharmaceutical powders; Cohesion; PARTICLE; FLOWABILITY; VIBRATION;
D O I
10.1016/j.ijpharm.2011.12.012
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Improvement in flow and bulk density, the two most important properties that determine the ease with which pharmaceutical powders can be handled, stored and processed, is done through surface modification. A limited design of experiment was conducted to establish a standardized dry coating procedure that limits the extent of powder attrition, while providing the most consistent improvement in angle of repose (AOR). The magnetically assisted impaction coating (MAIC) was considered as a model dry-coater for pharmaceutical powders; ibuprofen, acetaminophen, and ascorbic acid. Dry coated drug powders were characterized by AOR, particle size as a function of dispersion pressure, particle size distribution, conditioned bulk density (CBD), Carr index (CI), flow function coefficient (FFC), cohesion coefficient using different instruments, including a shear cell in the Freeman FT4 powder rheometer, and Hansen flowability index. Substantial improvement was observed in all the measured properties after dry coating relative to the uncoated powders, such that each powder moved from a poorer to a better flow classification and showed improved dispersion. The material intrinsic property such as cohesion, plotted as a function of particle size, gave a trend similar to those of bulk flow properties, AOR and Cl. Property improvement is also illustrated in a phase map of inverse cohesion (or FFC) as a function of bulk density, which also indicated a significant positive shift due to dry coating. It is hoped that such phase maps are useful in manufacturing decisions regarding the need for dry coating, which will allow moving from wet granulation to roller compaction or to direct compression based formulations. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:213 / 225
页数:13
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