Biological activity of complexes derived from thiophene-2-carbaldehyde thiosemicarbazone.: Crystal structure of [Ni(C6H6N3S2)2]

被引：83
作者：
García-Tojal, J
Pizarro, JL
García-Orad, A
Pérez-Sanz, AR
Ugalde, M
Díaz, AA
Serra, JL
Arriortua, MI
Rojo, T
机构：
[1] Univ Basque Country, Dept Quim Inorgan, E-48080 Bilbao, Spain
[2] Univ Burgos, Dept Quim, Burgos 09001, Spain
[3] Univ Basque Country, Dept Mineral Petrol, E-48080 Bilbao, Spain
[4] Univ Basque Country, Dept Biol Anim & Genet, E-48080 Bilbao, Spain
[5] Univ Basque Country, Dept Biol Celular & Ciencias Morfol, E-48080 Bilbao, Spain
[6] Univ Basque Country, Dept Bioquim & Biol Mol, E-48080 Bilbao, Spain
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2001年 / 86卷 / 2-3期
关键词：
thiophene-2-carbaldehyde thiosemicarbazone; structure-activity correlations;
D O I：
10.1016/S0162-0134(01)00210-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The crystal structure of [Ni(L-III)(2)] (1), where HLIII = thiophene-2-carbaldehyde thiosemicarbazone, consists of monomeric entities where the nickel(II) ions exhibit distorted square planar geometry. The two bidentate thiosemicarbazone ligands are centrosymmetric. (CS)-S-... van der Waals' links and nonbonded intramolecular interactions are present in the structure. The biological activity of 1 is compared to that of the free ligand, and the cobalt (III) (2) and copper(H) (3) derivatives. The observed order of cytotoxicity against melanoma B16F10 and Friend erythroleukemia. cells is: 1 less than or equal to ligand <2 <3. A structure-activity correlation using Extended-Huckel MO calculations is described. (C) 2001 Elsevier Science BY All rights reserved.
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收藏
页码：627 / 633
页数：7
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