Curcumin-induced cell death in two leukemia cell lines: K562 and Jurkat

被引：40

作者：

Duvoix, A

Morceau, F

Schnekenburger, M

Delhalle, S

Galteau, MM

Dicato, M

Diederich, M

机构：

[1] Ctr Univ Luxembourg, Lab RCMS, L-1511 Luxembourg, Luxembourg

[2] Univ Nancy 1, Fac Pharm, Lab Thiols & Fonct Cellulaires, F-54000 Nancy, France

来源：

APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS | 2003年 / 1010卷

关键词：

curcumin; leukemia; apoptosis;

D O I：

10.1196/annals.1299.071

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Curcumin presents strong antioxidant and anticancer properties. However, molecular mechanisms leading to curcumin-induced cell death are poorly understood. The effect of curcumin was compared in two different leukemia cell lines: K562 and Jurkat. Cell death was induced in both cell lines, and apoptosis pathways were investigated by Western blot analysis. Decreases in pro-caspase 8 and 9 levels were observed. BH3 interacting domain death agonist (Bid) was also cleaved. Jurkat cells appeared to be more sensitive to curcumin, and apoptosis takes place earlier.

引用

页码：389 / 392

页数：4

共 6 条

[1] Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis [J].