Plasma 25-Hydroxyvitamin D Levels Are Favorably Associated With β-Cell Function

被引：47
作者：
Karnchanasorn, Rudruidee [1 ,2 ]
Ou, Horng-Yih [3 ]
Chiu, Ken C. [1 ,2 ]
机构：
[1] City Hope Natl Med Ctr, Dept Clin Diabet Endocrinol & Metab, Duarte, CA 91010 USA
[2] Harbor UCLA Med Ctr, Dept Internal Med, Div Endocrinol Metab & Nutr, Torrance, CA 90509 USA
[3] Natl Cheng Kung Univ, Med Coll & Hosp, Dept Internal Med, Div Endocrinol & Metab, Tainan 70101, Taiwan
来源：
PANCREAS | 2012年 / 41卷 / 06期
关键词：
type; 2; diabetes; beta-cell function; insulin resistance; vitamin D; VITAMIN-D DEFICIENCY; DEPENDENT DIABETES-MELLITUS; 1,25 DIHYDROXYVITAMIN D-3; INSULIN SENSITIVITY; SERUM; 25-HYDROXYVITAMIN-D; GLUCAGON-SECRETION; NATIONAL-HEALTH; US POPULATION; TARGET-CELLS; RESISTANCE;
D O I：
10.1097/MPA.0b013e31823c947c
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Objective: The association of hypovitaminosis D with type 2 diabetes is well recognized. Although hypovitaminosis D is associated with insulin resistance, there is much less information about its impact on beta-cell function in humans. Methods: We enrolled 150 healthy, glucose-tolerant subjects for the assessment of beta-cell function (acute insulin response) and insulin sensitivity index (ISI) using a hyperglycemic clamp. Adjusted beta-cell function (ABCF) was defined as the product of acute insulin response and ISI. The relations of plasma 25-hydroxyvitamin D [25(OH)D] level with insulin sensitivity and ABCF were examined. Results: Plasma 25(OH) D levels were positively associated with ABCF (P = 0.00004) and ISI (P < 0.00001). The associations remained significant after adjustment for age, sex, body mass index, physical activity, ethnicity, and season of study. Conclusions: Plasma 25(OH)D levels are positively association with both beta-cell function and insulin sensitivity. Our observations suggest the roles of vitamin D deficiency in the dual defect of type 2 diabetes.
引用
收藏
页码：863 / 868
页数：6
相关论文
共 50 条
[31]   Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels [J].
Jorde, Rolf ;
Figenschau, Yngve .
EUROPEAN JOURNAL OF NUTRITION, 2009, 48 (06) :349-354
[32]   QUANTIFICATION OF THE RELATIONSHIP BETWEEN INSULIN SENSITIVITY AND BETA-CELL FUNCTION IN HUMAN-SUBJECTS - EVIDENCE FOR A HYPERBOLIC FUNCTION [J].
KAHN, SE ;
PRIGEON, RL ;
MCCULLOCH, DK ;
BOYKO, EJ ;
BERGMAN, RN ;
SCHWARTZ, MW ;
NEIFING, JL ;
WARD, WK ;
BEARD, JC ;
PALMER, JP ;
PORTE, D .
DIABETES, 1993, 42 (11) :1663-1672
[33]   Insulin sensitivity in subjects with secondary hyperparathyroidism and the effect of a low serum 25-hydroxyvitamin D level on insulin sensitivity [J].
Kamycheva, E. ;
Jorde, R. ;
Figenschau, Y. ;
Haug, E. .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2007, 30 (02) :126-132
[34]   Association of Vitamin D With Insulin Resistance and β-Cell Dysfunction in Subjects at Risk for Type 2 Diabetes [J].
Kayaniyil, Sheena ;
Vieth, Reinhold ;
Retnakaran, Ravi ;
Knight, Julia A. ;
Qi, Ying ;
Gerstein, Hertzel C. ;
Perkins, Bruce A. ;
Harris, Stewart B. ;
Zinman, Bernard ;
Hanley, Anthony J. .
DIABETES CARE, 2010, 33 (06) :1379-1381
[35]   Targeting β-Cell Function Early in the Course of Therapy for Type 2 Diabetes Mellitus [J].
Leahy, Jack L. ;
Hirsch, Irl B. ;
Peterson, Kevin A. ;
Schneider, Doron .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (09) :4206-4216
[36]   1,25-DIHYDROXYVITAMIN-D(3) AND PANCREATIC BETA-CELL FUNCTION - VITAMIN-D RECEPTORS, GENE-EXPRESSION, AND INSULIN-SECRETION [J].
LEE, S ;
CLARK, SA ;
GILL, RK ;
CHRISTAKOS, S .
ENDOCRINOLOGY, 1994, 134 (04) :1602-1610
[37]   Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3 [J].
Maunsell, Z ;
Wright, DJ ;
Rainbow, SJ .
CLINICAL CHEMISTRY, 2005, 51 (09) :1683-1690
[38]   A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men [J].
Nagpal, J. ;
Pande, J. N. ;
Bhartia, A. .
DIABETIC MEDICINE, 2009, 26 (01) :19-27
[39]   VITAMIN-D DEFICIENCY INHIBITS PANCREATIC-SECRETION OF INSULIN [J].
NORMAN, AW ;
FRANKEL, BJ ;
HELDT, AM ;
GRODSKY, GM .
SCIENCE, 1980, 209 (4458) :823-825
[40]   EFFECTS OF VITAMIN-D ON INSULIN AND GLUCAGON-SECRETION IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].
ORWOLL, E ;
RIDDLE, M ;
PRINCE, M .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1994, 59 (05) :1083-1087
12345