IRE1, a Double-Edged Sword in Pre-miRNA Slicing and Cell Death

被引：60

作者：

Hassler, Justin ^{[1
,2
]}

Cao, Stewart S. ^{[1
,2
]}

Kaufman, Randal J. ^{[1
,2
]}

机构：

[1] Sanford Burnham Med Res Inst, Del E Webb Neurosci Aging and Stem Cell Res Ctr, La Jolla, CA 92037 USA

[2] Univ Michigan, Med Ctr, Dept Biol Chem, Ann Arbor, MI 48109 USA

来源：

DEVELOPMENTAL CELL | 2012年 / 23卷 / 05期

关键词：

THIOREDOXIN-INTERACTING PROTEIN; IRE1-ALPHA; XBP1;

D O I：

10.1016/j.devcel.2012.10.025

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

IRE1 alpha, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1 alpha as a cell-death executioner, showing that upon ER stress, IRE1 alpha degrades microRNAs to promote translation of caspase-2.

引用

页码：921 / 923

页数：3

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