Complete Response of Advanced Hepatocellular Carcinoma with Multiple Lung Metastases Treated with Sorafenib: A Case Report

被引：33

作者：

Inuzuka, Tadashi ^{[1
]}

Nishikawa, Hiroki

Sekikawa, Akira

Takeda, Haruhiko

Henmi, Shinichiro

Sakamoto, Azusa

Saito, Sumio

Kita, Ryuichi

Kimura, Toru

Osaki, Yukio

Kudo, Masatoshi ^{[2
]}

机构：

[1] Osaka Red Cross Hosp, Dept Gastroenterol & Hepatol, Tennouji Ku, Osaka 5438555, Japan

[2] Kinki Univ, Sch Med, Dept Gastroenterol & Hepatol, Osaka 589, Japan

来源：

ONCOLOGY | 2011年 / 81卷

关键词：

Hepatocellular carcinoma; Sorafenib; Hepatic necrosis; Lung metastasis; Complete response; COMPLETE REMISSION; SYSTEMIC THERAPY; CANCER;

D O I：

10.1159/000333279

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sorafenib, an oral multikinase inhibitor, has demonstrated clinical efficacy in patients with advanced hepatocellular carcinoma (HCC). However, in the SHARP trial (Sorafenib HCC Assessment Randomized Protocol trial) and the Asia-Pacific trial (conducted in the Asia-Pacific region), no cases of complete response (CR) were reported. Thereafter, only a relatively small number of CR cases were reported worldwide for sorafenib therapy. We herein report a case of CR in a patient treated with sorafenib for 4 months. The patient had advanced HCC with multiple lung metastases, and there has been no recurrence after 8 months following cessation of administration. To our knowledge, this is the first time a female treated with sorafenib alone for HCC has had a CR. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：152 / 157

页数：6

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