共 121 条
Gastric stimulation for weight loss
被引:21
作者:
Mizrahi, Meir
[1
,2
]
Ben Ya'acov, Ami
[1
,2
]
Ilan, Yaron
[1
,2
]
机构:
[1] Hebrew Univ Hadassah Med Ctr, Gastroenterol Unit, Jerusalem, Israel
[2] Hebrew Univ Hadassah Med Ctr, Liver Unit, Jerusalem, Israel
关键词:
Obesity;
Gastric stimulation;
Gastric motility;
External pacing;
Gastric pacing;
Intestinal pacing;
GLUCAGON-LIKE PEPTIDE-1;
REDUCES FOOD-INTAKE;
PLASMA GHRELIN LEVELS;
ELECTRICAL-STIMULATION;
MORBID-OBESITY;
ARCUATE NUCLEUS;
POSTPRANDIAL CONCENTRATIONS;
ACYLATED PEPTIDE;
LEPTIN RECEPTOR;
GUT HORMONE;
D O I:
10.3748/wjg.v18.i19.2309
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
The prevalence of obesity is growing to epidemic proportions, and there is clearly a need for minimally invasive therapies with few adverse effects that allow for sustained weight loss. Behavior and lifestyle therapy are safe treatments for obesity in the short term, but the durability of the weight loss is limited. Although promising obesity drugs are in development, the currently available drugs lack efficacy or have unacceptable side effects. Surgery leads to long-term weight loss, but it is associated with morbidity and mortality. Gastric electrical stimulation (GES) has received increasing attention as a potential tool for treating obesity and gastrointestinal dysmotility disorders. GES is a promising, minimally invasive, safe, and effective method for treating obesity. External gastric pacing is aimed at alteration of the motility of the gastrointestinal tract in a way that will alter absorption due to alteration of transit time. In addition, data from animal models and preliminary data from human trials suggest a role for the gut-brain axis in the mechanism of GES. This may involve alteration of secretion of hormones associated with hunger or satiety. Patient selection for gastric stimulation therapy seems to be an important determinant of the treatment's outcome. Here, we review the current status, potential mechanisms of action, and possible future applications of gastric stimulation for obesity. (c) 2012 Baishideng. All rights reserved.
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页码:2309 / 2319
页数:11
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