Seroprevalence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 Among Healthcare Workers in Kenya

被引：23

作者：

Etyang, Anthony O. ^{[1
]}

Lucinde, Ruth ^{[1
]}

Karanja, Henry ^{[1
]}

Kalu, Catherine ^{[1
]}

Mugo, Daisy ^{[1
]}

Nyagwange, James ^{[1
]}

Gitonga, John ^{[1
]}

Tuju, James ^{[1
]}

Wanjiku, Perpetual ^{[1
]}

Karani, Angela ^{[1
]}

Mutua, Shadrack ^{[1
]}

Maroko, Hosea ^{[2
]}

Nzomo, Eddy ^{[3
]}

Maitha, Eric ^{[4
]}

Kamuri, Evanson ^{[5
]}

Kaugiria, Thuranira ^{[5
]}

Weru, Justus ^{[5
]}

Ochola, Lucy B. ^{[6
]}

Kilimo, Nelson ^{[7
]}

Charo, Sande ^{[8
]}

Emukule, Namdala ^{[9
]}

Moracha, Wycliffe ^{[10
]}

Mukabi, David ^{[10
]}

Okuku, Rosemary ^{[10
]}

Ogutu, Monicah ^{[10
]}

Angujo, Barrack ^{[1
]}

Otiende, Mark ^{[1
]}

Bottomley, Christian ^{[11
]}

Otieno, Edward ^{[1
]}

Ndwiga, Leonard ^{[1
]}

Nyaguara, Amek ^{[1
]}

Voller, Shirine ^{[1
,11
]}

Agoti, Charles N. ^{[1
]}

Nokes, David James ^{[1
]}

Ochola-Oyier, Lynette Isabella ^{[1
]}

Aman, Rashid ^{[12
]}

Amoth, Patrick ^{[12
]}

Mwangangi, Mercy ^{[12
]}

Kasera, Kadondi ^{[12
]}

Ng'ang'a, Wangari ^{[13
]}

Adetifa, Ifedayo M. O. ^{[1
,11
]}

Kagucia, E. Wangeci ^{[1
]}

Gallagher, Katherine ^{[1
,11
]}

Uyoga, Sophie ^{[1
]}

Tsofa, Benjamin ^{[1
]}

Barasa, Edwine ^{[1
]}

Bejon, Philip ^{[1
,14
]}

Scott, J. Anthony G. ^{[1
,11
]}

Agweyu, Ambrose ^{[1
]}

Warimwe, George M. ^{[1
,14
]}

机构：

[1] KEMRI Wellcome Trust Res Programme, Kilifi, Kenya

[2] KEMRI Ctr Infect & Parasit Dis Control Res, Alupe, Kenya

[3] Kilifi Cty Hosp, Kilifi, Kenya

[4] Dept Hlth, Kilifi, Kilifi County, Kenya

[5] Kenyatta Natl Hosp, Nairobi, Kenya

[6] Alupe Sub Cty Hosp, Busia, Kenya

[7] Inst Primate Res, Nairobi, Kenya

[8] Kocholia Subcty Hosp, Busia, Kenya

[9] Busia Cty Referral Hosp, Busia, Kenya

[10] Dept Hlth, Busia, Busia County, Kenya

[11] London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, London, England

[12] Govt Kenya, Minist Hlth, Nairobi, Kenya

[13] Govt Kenya, Presidential Policy & Strategy Unit, Nairobi, Kenya

[14] Univ Oxford, Nuffield Dept Med, Oxford, England

来源：

CLINICAL INFECTIOUS DISEASES | 2022年 / 74卷 / 02期

基金：

英国惠康基金; 比尔及梅琳达.盖茨基金会; 英国医学研究理事会;

关键词：

SARS-CoV-2; Healthcare Workers; Antibodies; Seroprevalence;

D O I：

10.1093/cid/ciab346

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study of antibodies to severe acute respiratory syndrome coronavirus 2 among healthcare workers in 3 counties in Kenya, we found significant regional differences in seroprevalence but no differences according to professional cadre. Background Few studies have assessed the seroprevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers (HCWs) in Africa. We report findings from a survey among HCWs in 3 counties in Kenya. Methods We recruited 684 HCWs from Kilifi (rural), Busia (rural), and Nairobi (urban) counties. The serosurvey was conducted between 30 July and 4 December 2020. We tested for immunoglobulin G antibodies to SARS-CoV-2 spike protein, using enzyme-linked immunosorbent assay. Assay sensitivity and specificity were 92.7 (95% CI, 87.9-96.1) and 99.0% (95% CI, 98.1-99.5), respectively. We adjusted prevalence estimates, using bayesian modeling to account for assay performance. Results The crude overall seroprevalence was 19.7% (135 of 684). After adjustment for assay performance, seroprevalence was 20.8% (95% credible interval, 17.5%-24.4%). Seroprevalence varied significantly (P < .001) by site: 43.8% (95% credible interval, 35.8%-52.2%) in Nairobi, 12.6% (8.8%-17.1%) in Busia and 11.5% (7.2%-17.6%) in Kilifi. In a multivariable model controlling for age, sex, and site, professional cadre was not associated with differences in seroprevalence. Conclusion These initial data demonstrate a high seroprevalence of antibodies to SARS-CoV-2 among HCWs in Kenya. There was significant variation in seroprevalence by region, but not by cadre.

引用

页码：288 / 293

页数：6

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