Unfolded protein response in brain ischemia: A timely update

被引：53

作者：

Yang, Wei ^{[1
]}

Paschen, Wulf ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Anesthesiol, Box 3094,130 Sands Bldg,Res Dr, Durham, NC 27710 USA

[2] Duke Univ, Dept Neurobiol, Med Ctr, Durham, NC 27710 USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2016年 / 36卷 / 12期

基金：

美国国家卫生研究院;

关键词：

Brain ischemia; endoplasmic reticulum; myocardial ischemia; stroke; unfolded protein response; ENDOPLASMIC-RETICULUM STRESS; TRANSIENT CEREBRAL-ISCHEMIA; NEURONAL CELL-DEATH; XBP1; MESSENGER-RNA; ER STRESS; TRANSCRIPTION FACTOR; CALCIUM HOMEOSTASIS; MAMMALIAN-CELLS; GENE-EXPRESSION; TRANSGENIC MICE;

D O I：

10.1177/0271678X16674488

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Folding and processing newly synthesized proteins are vital functions of the endoplasmic reticulum that are sensitive to a variety of stress conditions. The unfolded protein response is activated to restore endoplasmic reticulum function impaired by stress. While we know that brain ischemia impairs endoplasmic reticulum function, the role of unfolded protein response activation in post-ischemic recovery of neurologic function is only beginning to emerge. Here, we summarize what is known about endoplasmic reticulum stress and unfolded protein response in brain ischemia and discuss recent findings from myocardial ischemia studies that could help to advance research on endoplasmic reticulum stress and unfolded protein response in brain ischemia.

引用

页码：2044 / 2050

页数：7

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