Apratoxin D, a potent cytotoxic cyclodepsipeptide from Papua New Guinea collections of the marine cyanobacteria Lyngbya majuscula and Lyngbya sordida

被引：122

作者：

Gutierrez, Marcelino ^{[1
,2
]}

Suyama, Takashi L. ^{[1
,2
]}

Engene, Niclas ^{[1
,2
]}

Wingerd, Joshua S. ^{[1
,2
]}

Matainaho, Teatulohi ^{[3
]}

Gerwick, William H. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

[3] Univ Papua New Guinea, Discipline Pharmacol, Sch Med & Hlth Sci, Waigani, Papua N Guinea

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 06期

关键词：

D O I：

10.1021/np800121a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Cancer cell toxicity-guided fractionation of extracts of the Papua New Guinea marine cyanobacteria Lyngbya majuscula and Lyngbya sordida led to the isolation of apratoxin D (1). Compound I contains the same macrocycle as apratoxins A and C but possesses the novel 3,7-dihydroxy-2,5,8,10,10-pentamethylundecanoic acid as the polyketide moiety. The planar structures and stereostructures of compound 1 were determined by extensive 1D and 2D NMR and MS data analyses and by comparison with the spectroscopic data of apratoxins A and C. Apratoxin D (1) showed potent in vitro cytotoxicity against H-460 human lung cancer cells with an IC50 value of 2.6 nM.

引用

页码：1099 / 1103

页数：5

共 20 条

[1]

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