Secretion of tissue plasminogen activator and plasminogen activator inhibitor 1 during cardiopulmonary bypass

被引:31
作者
Chandler, WL [1 ]
Velan, T [1 ]
机构
[1] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA
关键词
cardiopulmonary bypass; tissue plasminogen activator; plasminogen activator inhibitor; computer modeling;
D O I
10.1016/j.thromres.2003.11.006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Cardiopulmonary bypass (CPB) is associated with elevated tissue plasminogen activator (t-PA) levels during CPB and increased plasminogen activator inhibitor 1 (PAI-1) levels post-operatively. The goal of this study was to estimate the rate of t-PA and PAI-1 secretion in vivo, before, during and after CPB. Materials and methods: Estimated rates of t-PA and PAI-1 secretion were based on measured levels of active and total t-PA, and active and total PAI-1, obtained before, during and after CPB from nine males, combined with a computer model of each patient's vascular system that continuously accounted for secretion, clearance, hemodilution, blood loss and transfusion. Results and conclusions: At baseline, the average t-PA and PAI-1 secretion rates were 0.74 +/- 0.33 and 1.28 +/- 0.74 pmol/s, respectively. Within 5 min of CPB initiation, t-PA secretion increased six-fold to 4.41 +/- 2.58 pmol/s, while PAI-1 secretion was unchanged, resulting in a six-fold increase in active t-PA levels. t-PA secretion remained elevated throughout CPB and into the early post-operative period. Average PAI-1 secretion did not start to increase until the end of CPB. By 2 It after surgery, average PAI-1 secretion had increased 15-fold to 19.60 +/- 17.10 pmol/s, resulting in reduced levels of active t-PA even though t-PA secretion was still elevated. We conclude that CPB induces an immediate sustained increase in t-PA secretion followed by a delayed progressive increase in PAI-1 production. Variations in the level of active t-PA are a function of the relative rates of t-PA versus PAI-1 secretion at different times during and after surgery. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:185 / 192
页数:8
相关论文
共 50 条
[41]   Expression of tissue type plasminogen activator and type 1 plasminogen activator inhibitor, and persistent fibrin deposition in chronic renal allograft failure [J].
Wang, YM ;
Pratt, JR ;
Hartley, B ;
Evans, B ;
Zhang, LN ;
Sacks, SH .
KIDNEY INTERNATIONAL, 1997, 52 (02) :371-377
[42]   Dynamic changes in plasma tissue plasminogen activator, plasminogen activator inhibitor-1 and beta-thromboglobulin content in ischemic stroke [J].
Zhuang, Ping ;
Wo, Da ;
Xu, Zeng-guang ;
Wei, Wei ;
Mao, Hui-ming .
JOURNAL OF CLINICAL NEUROSCIENCE, 2015, 22 (07) :1123-1127
[43]   EFFECT OF DEXTRAN ON PLASMA TISSUE-PLASMINOGEN ACTIVATOR (T-PA) AND PLASMINOGEN-ACTIVATOR INHIBITOR-1 (PAI-1) DURING SURGERY [J].
ERIKSSON, M ;
SALDEEN, T .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1995, 39 (02) :163-166
[44]   Rapamycin Affects Tissue Plasminogen Activator and Plasminogen Activator Inhibitor 1 Expression: A Potential Prothrombotic Mechanism of Drug-Eluting Stents [J].
Ma, Qian ;
Zhou, Yujie ;
Nie, Xiaomin ;
Yu, Miao ;
Gao, Fei ;
Wang, Zhijian ;
Ge, Hailong ;
Jia, Dean ;
Yang, Shiwei ;
Liu, Xiaoli ;
Han, Hongya ;
Hu, Bin ;
Shen, Hua ;
Xu, Xiaohan .
ANGIOLOGY, 2012, 63 (05) :330-335
[45]   Evaluation of Prognostic Values of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Crimean-Congo Hemorrhagic Fever Patients [J].
Gurbuz, Yunus ;
Ozturk, Baris ;
Tutuncu, Emin Ediz ;
Sencan, Irfan ;
Senturk, Gonul Cicek ;
Altay, Fatma Aybala .
JUNDISHAPUR JOURNAL OF MICROBIOLOGY, 2015, 8 (10)
[46]   TISSUE-PLASMINOGEN ACTIVATOR, PLASMINOGEN-ACTIVATOR INHIBITOR-1 AND VON-WILLEBRAND-FACTOR IN RHEUMATOID-ARTHRITIS [J].
WALLBERGJONSSON, S ;
DAHLEN, GH ;
NILSSON, TK ;
RANBY, M ;
RANTAPAADAHLQVIST, S .
CLINICAL RHEUMATOLOGY, 1993, 12 (03) :318-324
[47]   Expression of Recombinant Tissue Plasminogen Activator - Plasminogen Activator Inhibitor Complex in Mammal Cells as Quality Control Materials in Immunoassay [J].
Yang, Yiqi ;
Zhang, Zhigao ;
Luo, Huanchang ;
Chen, Changxu ;
Liu, Tiancai ;
Lin, Guanfeng ;
Wu, Yingsong .
PROTEIN JOURNAL, 2025, 44 (02) :245-255
[48]   Increasing expression of tissue plasminogen activator and plasminogen activator inhibitor type 2 in dog gingival tissues with progressive inflammation [J].
Lindberg, P ;
Kinnby, B ;
Lecander, I ;
Lang, NP ;
Matsson, L .
ARCHIVES OF ORAL BIOLOGY, 2001, 46 (01) :23-31
[49]   Roles of tissue plasminogen activator and its inhibitor in proliferative diabetic retinopathy [J].
Wu, Shu-Ling ;
Zhan, Dong-Mei ;
Xi, Shu-Hong ;
He, Xiang-Lian .
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, 2014, 7 (05) :764-767
[50]   Roles of tissue plasminogen activator and its inhibitor in proliferative diabetic retinopathy [J].
Shu-Ling Wu ;
Dong-Mei Zhan ;
Shu-Hong Xi ;
Xiang-Lian He .
International Journal of Ophthalmology, 2014, (05) :764-767