MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS)

被引:9
作者
Diamanti, Luca [1 ]
Paoletti, Matteo [1 ]
Di Vita, Umberto [2 ]
Muzic, Shaun Ivan [2 ]
Cereda, Cristina [1 ]
Ballante, Elena [1 ,2 ]
Pichiecchio, Anna [1 ,2 ]
机构
[1] IRCCS Mondino Fdn, I-27100 Pavia, Italy
[2] Univ Pavia, Dept Brain & Behav Sci, I-27100 Pavia, Italy
关键词
amyotrophic lateral sclerosis; muscle magnetic resonance imaging; biomarkers; electromyography; muscle damage; PARKINSONS-DISEASE; PISA SYNDROME;
D O I
10.3390/jcm9040934
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: the study of paraspinal muscles is pivotal for the diagnosis and staging of Amyotrophic Lateral Sclerosis (ALS), and is usually performed by electromyography. Objective: to evaluate the role of paraspinal muscle MRI as a diagnostic biomarker in ALS. Methods: we evaluated T1-w images of newly diagnosed ALS patients (n = 14), age-matched healthy controls (n = 11), patients affected by inflammatory myopathy (n = 10), and lumbar radiculopathy (n = 19), and compared them semiquantitatively by using the Mercuri Scale. Results: a significant difference in the appearance of the psoas muscle was observed between ALS patients and patients with radiculopathy (p = 0.003); after stratifying ALS patients into spinal and bulbar onsets, we found a significant difference in the appearance of the longissimus dorsi muscle between the spinal onset ALS subgroup and bulbar onset ALS subgroup (p = 0.0245), while no difference was found for multifidus (p = 0.1441), iliocostal (p = 0.0655), and psoas muscles (p = 0.0813) between the cohort subgroups. Conclusions: paraspinal T1-w MRI could help to distinguish spinal ALS patients from healthy and pathological controls. Specifically, the study of longissimus dorsi could play the role of a diagnostic ALS biomarker.
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页数:6
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