Glutamine Metabolism and Its Role in the Therapy of Cancer

被引：0
作者：
Vrzackova, Nikola [1 ]
Ruml, Tomas [1 ]
Zelenka, Jaroslav [1 ]
机构：
[1] Vysoka Skola Chem Technol Praze, Ustav Biochem & Mikrobiol, Tech 3, Prague 16628, Czech Republic
来源：
CHEMICKE LISTY | 2020年 / 114卷 / 07期
关键词：
glutamine; cancer therapy; metabolism; AMINO-ACID TRANSPORTERS; KIDNEY-TYPE GLUTAMINASE; MAMMALIAN-CELLS; SUPPORTS GROWTH; BREAST-CANCER; GLUTATHIONE; MTOR; BIOLOGY; CARBOXYLATION; INHIBITION;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Inhibition of selected metabolic pathways is a hot topic in current cancer therapy. This is caused by the fact that metabolic transformation across different types of cancer cells is highly similar and, on the other hand, significantly different from the non-cancer cells. In this regard, glutamine is especially interesting because it serves not only as a donor of carbon skeletons and amino groups for the cell anabolism but also as a substrate involved in the energetic metabolism, redox homeostasis, and antioxidant protection. Therapeutic aiming at the glutamine metabolism offers a significant opportunity to improve the prognosis of cancer patients.
引用
收藏
页码：430 / 436
页数：7
相关论文
共 65 条
[1]   Redox control of glutamine utilization in cancer [J].
Alberghina, L. ;
Gaglio, D. .
CELL DEATH & DISEASE, 2014, 5 :e1561-e1561
[2]   From Krebs to clinic: glutamine metabolism to cancer therapy [J].
Altman, Brian J. ;
Stine, Zachary E. ;
Dang, Chi V. .
NATURE REVIEWS CANCER, 2016, 16 (10) :619-634
[3]  
BANNAI S, 1986, J BIOL CHEM, V261, P2256
[4]   Glutamine transporters in mammalian cells and their functions in physiology and cancer [J].
Bhutia, Yangzom D. ;
Ganapathy, Vadivel .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2016, 1863 (10) :2531-2539
[5]   Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs [J].
Bhutia, Yangzom D. ;
Babu, Ellappan ;
Ramachandran, Sabarish ;
Ganapathy, Vadivel .
CANCER RESEARCH, 2015, 75 (09) :1782-1788
[6]   RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1 [J].
Burnett, PE ;
Barrow, RK ;
Cohen, NA ;
Snyder, SH ;
Sabatini, DM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) :1432-1437
[7]   Glutamine Synthetase: Localization Dictates Outcome [J].
Castegna, Alessandra ;
Menga, Alessio .
GENES, 2018, 9 (02)
[8]   Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach [J].
Chen, Lian ;
Cui, Hengmin .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (09) :22830-22855
[9]   Cancer-associated IDH1 mutations produce 2-hydroxyglutarate [J].
Dang, Lenny ;
White, David W. ;
Gross, Stefan ;
Bennett, Bryson D. ;
Bittinger, Mark A. ;
Driggers, Edward M. ;
Fantin, Valeria R. ;
Jang, Hyun Gyung ;
Jin, Shengfang ;
Keenan, Marie C. ;
Marks, Kevin M. ;
Prins, Robert M. ;
Ward, Patrick S. ;
Yen, Katharine E. ;
Liau, Linda M. ;
Rabinowitz, Joshua D. ;
Cantley, Lewis C. ;
Thompson, Craig B. ;
Heiden, Matthew G. Vander ;
Su, Shinsan M. .
NATURE, 2009, 462 (7274) :739-U52
[10]   Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer [J].
DeBerardinis, R. J. ;
Cheng, T. .
ONCOGENE, 2010, 29 (03) :313-324
1234567