Another way to not get eaten

被引:10
作者
Zhang, Cheng Cheng [1 ]
Fu, Yang-Xin [2 ]
机构
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Physiol, Dallas, TX USA
[2] Univ Texas Southwestern Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA
关键词
LEUKEMIA DEVELOPMENT; IMMUNE CHECKPOINT; DENDRITIC CELLS; TUMOR; CD47;
D O I
10.1038/s41590-017-0009-7
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A previously unknown role is identified for a pathway that involves major histocompatibility complex class I and an inhibitory receptor, LILRB1, that regulates the phagocytosis of cancer cells by macrophages and contributes to resistance directed against the signal-regulatory protein CD47.
引用
收藏
页码:6 / 7
页数:2
相关论文
共 13 条
[1]  
Barkal A. A., 2017, NAT IMMUNOL
[2]   Immunoglobulin-like transcript 3 is expressed by myeloid-derived suppressor cells and correlates with survival in patients with non-small cell lung cancer [J].
de Goeje, Pauline L. ;
Bezemer, Koen ;
Heuvers, Marlies E. ;
Dingemans, Anne-Marie C. ;
Groen, Harry J. M. ;
Smit, Egbert F. ;
Hoogsteden, Henk C. ;
Hendriks, Rudi W. ;
Aerts, Joachim G. J. V. ;
Hegmans, Joost P. J. J. .
ONCOIMMUNOLOGY, 2015, 4 (07) :1-11
[3]   MHC class I antigens, immune surveillance, and tumor immune escape [J].
Garcia-Lora, A ;
Algarra, I ;
Garrido, F .
JOURNAL OF CELLULAR PHYSIOLOGY, 2003, 195 (03) :346-355
[4]   Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors [J].
Kang, Xunlei ;
Kim, Jaehyup ;
Deng, Mi ;
John, Samuel ;
Chen, Heyu ;
Wu, Guojin ;
Phan, Hiep ;
Zhang, Cheng Cheng .
CELL CYCLE, 2016, 15 (01) :25-40
[5]   The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development [J].
Kang, Xunlei ;
Lu, Zhigang ;
Cui, Changhao ;
Deng, Mi ;
Fan, Yuqi ;
Dong, Baijun ;
Han, Xin ;
Xie, Fuchun ;
Tyner, Jeffrey W. ;
Coligan, John E. ;
Collins, Robert H. ;
Xiao, Xiangshu ;
You, M. James ;
Zhang, Cheng Cheng .
NATURE CELL BIOLOGY, 2015, 17 (05) :665-U286
[6]   Is CD47 an innate immune checkpoint for tumor evasion? [J].
Liu, Xiaojuan ;
Kwon, Hyunwoo ;
Li, Zihai ;
Fu, Yang-xin .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2017, 10 :1-7
[7]   CD47 blockade triggers T cell-mediated destruction of immunogenic tumors [J].
Liu, Xiaojuan ;
Pu, Yang ;
Cron, Kyle ;
Deng, Liufu ;
Kline, Justin ;
Frazier, William A. ;
Xu, Hairong ;
Peng, Hua ;
Fu, Yang-Xin ;
Xu, Meng Michelle .
NATURE MEDICINE, 2015, 21 (10) :1209-+
[8]   High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells [J].
Manavalan, JS ;
Rossi, PC ;
Vlad, G ;
Piazza, F ;
Yarilina, A ;
Cortesini, R ;
Mancini, D ;
Suciu-Foca, N .
TRANSPLANT IMMUNOLOGY, 2003, 11 (3-4) :245-258
[9]   Soluble Ig-like transcript 3 inhibits tumor allograft rejection in humanized SCID mice and T cell responses in cancer patients [J].
Suciu-Foca, Nicole ;
Feirt, Nikki ;
Zhang, Qing-Yin ;
Vlad, George ;
Liu, Zhuoru ;
Lin, Hana ;
Chang, Chih-Chao ;
Ho, Eric K. ;
Colovai, Adriana I. ;
Kaufman, Howard ;
D'Agati, Vivette D. ;
Thaker, Harshwardhan M. ;
Remotti, Helen ;
Galluzzo, Sara ;
Cinti, Paola ;
Rabitti, Carla ;
Allendorf, John ;
Chabot, John ;
Caricato, Marco ;
Coppola, Roberto ;
Berloco, Pasquale ;
Cortesini, Raffaello .
JOURNAL OF IMMUNOLOGY, 2007, 178 (11) :7432-7441
[10]   Myeloid Cell Origins, Differentiation, and Clinical Implications [J].
Weiskopf, Kipp ;
Schnorr, Peter J. ;
Pang, Wendy W. ;
Chao, Mark P. ;
Chhabra, Akanksha ;
Seita, Jun ;
Feng, Mingye ;
Weissman, Irving L. .
MICROBIOLOGY SPECTRUM, 2016, 4 (05)