Shrinkage of the myenteric neurons of the small intestine in patients with multiple system atrophy

被引：4

作者：

Ozawa, Tetsutaro ^{[1
]}

Shimizu, Hiroshi ^{[2
]}

Matsui, Hideaki ^{[3
]}

Onodera, Osamu ^{[4
]}

Kakita, Akiyoshi ^{[2
]}

机构：

[1] Niigata Univ, Uonuma Inst Community Med, Dept Neurol, Med & Dent Hosp, 4132 Urasa, Niigata 9497302, Japan

[2] Niigata Univ, Brain Res Inst, Dept Pathol, Niigata, Japan

[3] Niigata Univ, Ctr Transdisciplinary Res, Dept Neurosci Dis, Niigata, Japan

[4] Niigata Univ, Brain Res Inst, Dept Neurol, Niigata, Japan

来源：

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2019年 / 221卷

关键词：

Multiple system atrophy; Enteric neuron; Neurodegeneration; alpha-Synuclein; GLIAL CYTOPLASMIC INCLUSIONS; INVOLVEMENT;

D O I：

10.1016/j.autneu.2019.102583

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study aimed to determine whether enteric neurons are involved in multiple system atrophy (MSA). Four-mu m-thick slices of small intestine were prepared from 10%-formalin-fixed and paraffin-embedded materials obtained from autopsied cases. Enteric neurons were stained using an anti-peripherin antibody. Immunostaining of phosphorylated alpha-synuclein was also performed. Areas of the cytoplasm and nucleus that showed nucleoli were measured using computer software. Both areas of myenteric neurons were significantly smaller in MSA cases (n = 3) than in control subjects (n = 3) (P < 0.0001); however, no deposits of phosphorylated alpha-synuclein were observed. These findings suggest that myenteric neurons in MSA are affected independent of alpha-synuclein accumulation.

引用

页数：3

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