Cytokines, tumour-cell death and immunogenicity: A question of choice

被引：177
作者：
Musiani, P
Modesti, A
Giovarelli, M
Cavallo, F
Colombo, MP
Lollini, PL
Forni, G
机构：
[1] UNIV TORINO,DIPARTIMENTO SCI CLINICHE & BIOL,TURIN,ITALY
[2] UNIV TORINO,CNR,CIOS,TURIN,ITALY
[3] UNIV BOLOGNA,IST CANCEROL,BOLOGNA,ITALY
[4] IST NAZL TUMORI,I-20133 MILAN,ITALY
来源：
IMMUNOLOGY TODAY | 1997年 / 18卷 / 01期
关键词：
D O I：
10.1016/S0167-5699(97)80012-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
How do cytokines released by engineered tumour cells provoke tumour rejection and an immune memory? Is vaccination with tumour cells that have been engineered to secrete cytokines a viable therapeutic perspective? Pier Musiani and colleagues have sought an answer to these questions by transfecting the same tumour with the genes of various cytokines and elucidating the features of the reactions elicited.
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页码：32 / 36
页数：5
相关论文
共 38 条
[1]  
ALLIONE A, 1994, CANCER RES, V54, P6022
[2]   IMMUNITY TO METHYLCHOLANTHRENE-INDUCED TUMOURS IN INBRED RATS FOLLOWING ATROPHY AND REGRESSION OF THE IMPLANTED TUMOURS [J].
BALDWIN, RW .
BRITISH JOURNAL OF CANCER, 1955, 9 (04) :652-657
[3]   GROWTH-INHIBITION OF AN MC-INDUCED MOUSE SARCOMA BY TCGF (IL 2)-CONTAINING PREPARATIONS - PRELIMINARY-REPORT [J].
BUBENIK, J ;
PERLMANN, P ;
INDROVA, M ;
SIMOVA, J ;
JANDLOVA, T ;
NEUWIRT, J .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 1983, 14 (03) :205-206
[4]  
CAVALLO F, 1992, J IMMUNOL, V149, P3627
[5]   COEXPRESSION OF B7-1 AND ICAM-1 ON TUMORS IS REQUIRED FOR REJECTION AND THE ESTABLISHMENT OF A MEMORY RESPONSE [J].
CAVALLO, F ;
MARTINFONTECHA, A ;
BELLONE, M ;
HELTAI, S ;
GATTI, E ;
TORNAGHI, P ;
FRESCHI, M ;
FORNI, G ;
DELLABONA, P ;
CASORATI, G .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (05) :1154-1162
[6]  
CHANG HL, 1993, CANCER RES, V53, P4391
[7]  
CHEN L, 1994, CELL, V71, P1093
[8]  
COLOMBO MP, 1992, CANCER RES, V52, P4853
[9]   CYTOKINE GENE-TRANSFER IN TUMOR-INHIBITION AND TUMOR-THERAPY - WHERE ARE WE NOW [J].
COLOMBO, MP ;
FORNI, G .
IMMUNOLOGY TODAY, 1994, 15 (02) :48-51
[10]   GRANULOCYTE COLONY-STIMULATING FACTOR GENE-TRANSFER SUPPRESSES TUMORIGENICITY OF A MURINE ADENOCARCINOMA INVIVO [J].
COLOMBO, MP ;
FERRARI, G ;
STOPPACCIARO, A ;
PARENZA, M ;
RODOLFO, M ;
MAVILIO, F ;
PARMIANI, G .
JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (04) :889-897
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