Interleukin-8: A critical chemokine in biliary atresia

被引：48
作者：
Dong, Rui [1 ,2 ]
Zheng, Shan [1 ,2 ]
机构：
[1] Fudan Univ, Childrens Hosp, Dept Pediat Surg, Shanghai 201102, Peoples R China
[2] Minist Hlth, Key Lab Neonatal Dis, Shanghai 201102, Peoples R China
来源：
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2015年 / 30卷 / 06期
基金：
中国国家自然科学基金;
关键词：
biliary atresia; inflammation; interleukin-8; liver fibrosis; signaling; CHRONIC HEPATITIS-C; EPITHELIAL-MESENCHYMAL TRANSITION; GAMMA-GLUTAMYL-TRANSFERASE; GENE-EXPRESSION SIGNATURE; CHRONIC LIVER-DISEASE; NECROSIS-FACTOR-ALPHA; KAPPA-B PATHWAYS; BILE-DUCT INJURY; IL-8; EXPRESSION; SERUM INTERLEUKIN-8;
D O I：
10.1111/jgh.12900
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Biliary atresia (BA) is characterized by periductular inflammation and fibrosis and is associated with the progressive obliteration of the bile ducts. The induction and maintenance of systemic and local inflammatory responses plays a pivotal role in this process. Interleukin-8 (IL-8) is an important mediator of inflammation and the immune response in human disease. IL-8 is overexpressed in BA, and its expression positively correlates with inflammation and liver fibrosis. In this review, we focus on the available evidence, recent insights, and future clinical and preclinical possibilities regarding the role of IL-8 in BA.
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收藏
页码：970 / 976
页数：7
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