Selective Activation of Enantiotopic C(sp3)-Hydrogen by Means of Chiral Phosphoric Acid: Asymmetric Synthesis of Tetrahydroquinoline Derivatives

被引：231

作者：

Mori, Keiji ^{[1
]}

Ehara, Kensuke ^{[1
]}

Kurihara, Kazuki ^{[1
]}

Akiyama, Takahiko ^{[1
]}

机构：

[1] Gakushuin Univ, Dept Chem, Fac Sci, Toshima Ku, Tokyo 1718588, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 16期

基金：

日本学术振兴会;

关键词：

H BOND FUNCTIONALIZATION; RING-CLOSURE REACTIONS; HETEROCYCLIC SYNTHESIS; STEREOCHEMICAL ASPECTS; ALKYLATION REACTIONS; ALPHA-CYCLIZATION; TERTIARY-AMINES; ALKYNYL ETHERS; IN-SITU; MEMORY;

D O I：

10.1021/ja2014955

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chiral phosphoric acid-catalyzed asymmetric C-H functionalization has been achieved. In this process, enantiotopic C(sp(3))-hydrogen is selectively activated by chiral phosphoric acid to afford tetrahydroquinoline derivatives with excellent enantioselectivities (up to 97% ee).

引用

页码：6166 / 6169

页数：4

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