Schizophrenia: Genome, interrupted

被引:18
作者
Cantor, Rita M. [1 ,2 ]
Geschwind, Daniel H. [1 ,2 ,3 ]
机构
[1] Univ Calif Los Angeles, Dept Human Genet, David Geffen Sch Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Ctr Neurobehav Genet, Semel Inst, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Program Neurogenet, Dept Neurol, Los Angeles, CA 90095 USA
关键词
D O I
10.1016/j.neuron.2008.04.007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Structural chromosomal variation is increasingly recognized as an important contributor to human diseases, particularly those of neurodevelopment, such as autism. A current paper makes a significant advance to schizophrenia genetics by establishing an association with rare copy number variants (CNV), which are over-represented in neurodevelopmental genes.
引用
收藏
页码:165 / 167
页数:3
相关论文
共 15 条
  • [1] Diagnostic genome profiling in mental retardation
    de Vries, BBA
    Pfundt, R
    Leisink, M
    Koolen, DA
    Vissers, LELM
    Janssen, IM
    van Reijmersdal, S
    Nillesen, WM
    Huys, EHLPG
    de Leeuw, N
    Smeets, D
    Sistermans, EA
    Feuth, T
    van Ravenswaaij-Arts, CMA
    van Kessel, AG
    Schoenmakers, EFPM
    Brunner, HG
    Veltman, JA
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 77 (04) : 606 - 616
  • [2] Array-based comparative genomic hybridisation identifies high frequency of cryptic chromosomal rearrangements in patients with syndromic autism spectrum disorders
    Jacquemont, M-L
    Sanlaville, D.
    Redon, R.
    Raoul, O.
    Cormier-Daire, V.
    Lyonnet, S.
    Amiel, J.
    Le Merrer, M.
    Heron, D.
    de Blois, M-C
    Prieur, M.
    Vekemans, M.
    Carter, N. P.
    Munnich, A.
    Colleaux, L.
    Philippe, A.
    [J]. JOURNAL OF MEDICAL GENETICS, 2006, 43 (11) : 843 - 849
  • [3] Pathophysiologically based treatment interventions in schizophrenia
    Lewis, David A.
    Gonzalez-Burgos, Guillermo
    [J]. NATURE MEDICINE, 2006, 12 (09) : 1016 - 1022
  • [4] Genomic rearrangements and sporadic disease
    Lupski, James R.
    [J]. NATURE GENETICS, 2007, 39 (Suppl 7) : S43 - S47
  • [5] Structural variation of chromosomes in autism spectrum disorder
    Marshall, Christian R.
    Noor, Abdul
    Vincent, John B.
    Lionel, Anath C.
    Feuk, Lars
    Skaug, Jennifer
    Shago, Mary
    Moessner, Rainald
    Pinto, Dalila
    Ren, Yan
    Thiruvahindrapduram, Bhoorna
    Fiebig, Andreas
    Schreiber, Stefan
    Friedman, Jan
    Ketelaars, Cees E. J.
    Vos, Yvonne J.
    Ficicioglu, Can
    Kirkpatrick, Susan
    Nicolson, Rob
    Sloman, Leon
    Surnmers, Anne
    Gibbons, Clare A.
    Teebi, Ahmad
    Chitayat, David
    Weksberg, Rosanna
    Thompson, Ann
    Vardy, Cathy
    Crosbie, Vicki
    Luscombe, Sandra
    Baatjes, Rebecca
    Zwaigenbaum, Lonnie
    Roberts, Wendy
    Fernandez, Bridget
    Szatmari, Peter
    Scherer, Stephen W.
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (02) : 477 - 488
  • [6] Mehan Michael R., 2004, Human Genomics, V1, P335
  • [7] Association of the NRG1 gene and schizophrenia:: a meta-analysis
    Munafò, MR
    Thiselton, DL
    Clark, TG
    Flint, J
    [J]. MOLECULAR PSYCHIATRY, 2006, 11 (06) : 539 - 546
  • [8] An update on the genetics of schizophrenia
    Norton, N
    Williams, HJ
    Owen, MJ
    [J]. CURRENT OPINION IN PSYCHIATRY, 2006, 19 (02) : 158 - 164
  • [9] Strong association of de novo copy number mutations with autism
    Sebat, Jonathan
    Lakshmi, B.
    Malhotra, Dheeraj
    Troge, Jennifer
    Lese-Martin, Christa
    Walsh, Tom
    Yamrom, Boris
    Yoon, Seungtai
    Krasnitz, Alex
    Kendall, Jude
    Leotta, Anthony
    Pai, Deepa
    Zhang, Ray
    Lee, Yoon-Ha
    Hicks, James
    Spence, Sarah J.
    Lee, Annette T.
    Puura, Kaija
    Lehtimaeki, Terho
    Ledbetter, David
    Gregersen, Peter K.
    Bregman, Joel
    Sutcliffe, James S.
    Jobanputra, Vaidehi
    Chung, Wendy
    Warburton, Dorothy
    King, Mary-Claire
    Skuse, David
    Geschwind, Daniel H.
    Gilliam, T. Conrad
    Ye, Kenny
    Wigler, Michael
    [J]. SCIENCE, 2007, 316 (5823) : 445 - 449
  • [10] Discovery of previously unidentified genomic disorders from the duplication architecture of the human genome
    Sharp, Andrew J.
    Hansen, Sierra
    Selzer, Rebecca R.
    Cheng, Ze
    Regan, Regina
    Hurst, Jane A.
    Stewart, Helen
    Price, Sue M.
    Blair, Edward
    Hennekam, Raoul C.
    Fitzpatrick, Carrie A.
    Segraves, Rick
    Richmond, Todd A.
    Guiver, Cheryl
    Albertson, Donna G.
    Pinkel, Daniel
    Eis, Peggy S.
    Schwartz, Stuart
    Knight, Samantha J. L.
    Eichler, Evan E.
    [J]. NATURE GENETICS, 2006, 38 (09) : 1038 - 1042