Schizophrenia: Genome, interrupted

被引:18
作者
Cantor, Rita M. [1 ,2 ]
Geschwind, Daniel H. [1 ,2 ,3 ]
机构
[1] Univ Calif Los Angeles, Dept Human Genet, David Geffen Sch Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Ctr Neurobehav Genet, Semel Inst, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Program Neurogenet, Dept Neurol, Los Angeles, CA 90095 USA
关键词
D O I
10.1016/j.neuron.2008.04.007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Structural chromosomal variation is increasingly recognized as an important contributor to human diseases, particularly those of neurodevelopment, such as autism. A current paper makes a significant advance to schizophrenia genetics by establishing an association with rare copy number variants (CNV), which are over-represented in neurodevelopmental genes.
引用
收藏
页码:165 / 167
页数:3
相关论文
共 15 条
[1]   Diagnostic genome profiling in mental retardation [J].
de Vries, BBA ;
Pfundt, R ;
Leisink, M ;
Koolen, DA ;
Vissers, LELM ;
Janssen, IM ;
van Reijmersdal, S ;
Nillesen, WM ;
Huys, EHLPG ;
de Leeuw, N ;
Smeets, D ;
Sistermans, EA ;
Feuth, T ;
van Ravenswaaij-Arts, CMA ;
van Kessel, AG ;
Schoenmakers, EFPM ;
Brunner, HG ;
Veltman, JA .
AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 77 (04) :606-616
[2]   Array-based comparative genomic hybridisation identifies high frequency of cryptic chromosomal rearrangements in patients with syndromic autism spectrum disorders [J].
Jacquemont, M-L ;
Sanlaville, D. ;
Redon, R. ;
Raoul, O. ;
Cormier-Daire, V. ;
Lyonnet, S. ;
Amiel, J. ;
Le Merrer, M. ;
Heron, D. ;
de Blois, M-C ;
Prieur, M. ;
Vekemans, M. ;
Carter, N. P. ;
Munnich, A. ;
Colleaux, L. ;
Philippe, A. .
JOURNAL OF MEDICAL GENETICS, 2006, 43 (11) :843-849
[3]   Pathophysiologically based treatment interventions in schizophrenia [J].
Lewis, David A. ;
Gonzalez-Burgos, Guillermo .
NATURE MEDICINE, 2006, 12 (09) :1016-1022
[4]   Genomic rearrangements and sporadic disease [J].
Lupski, James R. .
NATURE GENETICS, 2007, 39 (Suppl 7) :S43-S47
[5]   Structural variation of chromosomes in autism spectrum disorder [J].
Marshall, Christian R. ;
Noor, Abdul ;
Vincent, John B. ;
Lionel, Anath C. ;
Feuk, Lars ;
Skaug, Jennifer ;
Shago, Mary ;
Moessner, Rainald ;
Pinto, Dalila ;
Ren, Yan ;
Thiruvahindrapduram, Bhoorna ;
Fiebig, Andreas ;
Schreiber, Stefan ;
Friedman, Jan ;
Ketelaars, Cees E. J. ;
Vos, Yvonne J. ;
Ficicioglu, Can ;
Kirkpatrick, Susan ;
Nicolson, Rob ;
Sloman, Leon ;
Surnmers, Anne ;
Gibbons, Clare A. ;
Teebi, Ahmad ;
Chitayat, David ;
Weksberg, Rosanna ;
Thompson, Ann ;
Vardy, Cathy ;
Crosbie, Vicki ;
Luscombe, Sandra ;
Baatjes, Rebecca ;
Zwaigenbaum, Lonnie ;
Roberts, Wendy ;
Fernandez, Bridget ;
Szatmari, Peter ;
Scherer, Stephen W. .
AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (02) :477-488
[6]  
Mehan Michael R., 2004, Human Genomics, V1, P335
[7]   Association of the NRG1 gene and schizophrenia:: a meta-analysis [J].
Munafò, MR ;
Thiselton, DL ;
Clark, TG ;
Flint, J .
MOLECULAR PSYCHIATRY, 2006, 11 (06) :539-546
[8]   An update on the genetics of schizophrenia [J].
Norton, N ;
Williams, HJ ;
Owen, MJ .
CURRENT OPINION IN PSYCHIATRY, 2006, 19 (02) :158-164
[9]   Strong association of de novo copy number mutations with autism [J].
Sebat, Jonathan ;
Lakshmi, B. ;
Malhotra, Dheeraj ;
Troge, Jennifer ;
Lese-Martin, Christa ;
Walsh, Tom ;
Yamrom, Boris ;
Yoon, Seungtai ;
Krasnitz, Alex ;
Kendall, Jude ;
Leotta, Anthony ;
Pai, Deepa ;
Zhang, Ray ;
Lee, Yoon-Ha ;
Hicks, James ;
Spence, Sarah J. ;
Lee, Annette T. ;
Puura, Kaija ;
Lehtimaeki, Terho ;
Ledbetter, David ;
Gregersen, Peter K. ;
Bregman, Joel ;
Sutcliffe, James S. ;
Jobanputra, Vaidehi ;
Chung, Wendy ;
Warburton, Dorothy ;
King, Mary-Claire ;
Skuse, David ;
Geschwind, Daniel H. ;
Gilliam, T. Conrad ;
Ye, Kenny ;
Wigler, Michael .
SCIENCE, 2007, 316 (5823) :445-449
[10]   Discovery of previously unidentified genomic disorders from the duplication architecture of the human genome [J].
Sharp, Andrew J. ;
Hansen, Sierra ;
Selzer, Rebecca R. ;
Cheng, Ze ;
Regan, Regina ;
Hurst, Jane A. ;
Stewart, Helen ;
Price, Sue M. ;
Blair, Edward ;
Hennekam, Raoul C. ;
Fitzpatrick, Carrie A. ;
Segraves, Rick ;
Richmond, Todd A. ;
Guiver, Cheryl ;
Albertson, Donna G. ;
Pinkel, Daniel ;
Eis, Peggy S. ;
Schwartz, Stuart ;
Knight, Samantha J. L. ;
Eichler, Evan E. .
NATURE GENETICS, 2006, 38 (09) :1038-1042