ZnO Tips Dotted with Au Nanoparticles-Advanced SERS Determination of Trace Nicotine

被引：6

作者：

Cao, Jiaying ^{[1
]}

Zhai, Yan ^{[1
]}

Tang, Wanxin ^{[1
]}

Guo, Xiaoyu ^{[1
]}

Wen, Ying ^{[1
]}

Yang, Haifeng ^{[1
]}

机构：

[1] Shanghai Normal Univ, Coll Chem & Mat Sci, Educ Minist Key Lab Resource Chem, Shanghai 200234, Peoples R China

来源：

BIOSENSORS-BASEL | 2021年 / 11卷 / 11期

基金：

中国国家自然科学基金;

关键词：

SERS; ZnO tips; nicotine; AuNPs; ENHANCED RAMAN-SCATTERING; IN-SITU SYNTHESIS; RAPID DETECTION; AG NANOPARTICLES; LIQUID-CHROMATOGRAPHY; RAT PLASMA; SURFACE; QUANTIFICATION; SPECTROSCOPY; COTININE;

D O I：

10.3390/bios11110465

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Long-term exposure to nicotine causes a variety of human diseases, such as lung damage/adenocarcinoma, nausea and vomiting, headache, incontinence and heart failure. In this work, as a surface-enhanced Raman scattering (SERS) substrate, zinc oxide (ZnO) tips decorated with gold nanoparticles (AuNPs) are fabricated and designated as ZnO/Au. Taking advantage of the synergistic effect of a ZnO semiconductor with morphology of tips and AuNPs, the ZnO/Au-based SERS assay for nicotine demonstrates high sensitivity and the limit of detection 8.9 x 10(-12) mol/L is reached, as well as the corresponding linear dynamic detection range of 10(-10)-10(-6) mol/L. Additionally, the signal reproducibility offered by the SERS substrate could realize the reliable determination of trace nicotine in saliva.

引用

页数：10

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