Sleep Apnea, Reproductive Hormones and Quality of Sexual Life in Severely Obese Men

The effect of sleep apnea on the reproductive function of obese men is not entirely elucidated. The objective of this study was to define the effect of sleep apnea on the reproductive hormones and sexual function in obese men. This study included 89 severely obese men with BMI >= 35 kg/m(2) considering gastric bypass surgery. Anthropometrics (weight, and BMI), reproductive hormones, and sleep studies were measured. The sexual quality of life was assessed using the Impact of Weight on Quality of Life-Lite questionnaire (IWQOL-Lite). The mean age of our patients was 46.9 +/- 11.0 years, the mean BMI was 47.8 +/- 8.7 kg/m(2) and the mean weight was 337.7 +/- 62.4 lb. After correction for age and BMI, means of free testosterone per severity group of sleep apnea were as follows: no or mild sleep apnea 74.4 +/- 3.8 pg/ml, moderate sleep apnea 68.6 +/- 4.2 pg/ml, and severe sleep apnea 60.2 +/- 2.92 pg/ml, P = 0.014. All other parameters of sleep apnea including hypopnea index, percent time below a SpO(2) of 90%, and percent time below a SpO(2) of 80% were also negatively correlated with testosterone levels after correction for age and BMI. BMI and presence of coronary artery disease decreased the sexual quality of life. Sleep apnea was associated with reduced sexual quality of life. In summary, sleep apnea negatively affects testosterone levels independent of BMI. Severely obese men had decreased sexual quality of life.