Cholestane and spirostane glycosides from the rhizomes of Dioscorea septemloba

被引：42

作者：

Liu, Xue-Ting ^{[1
]}

Wang, Zhen-Zhong ^{[2
]}

Xiao, Wei ^{[2
]}

Zhao, Hui-Wu ^{[2
]}

Hu, Jie ^{[1
]}

Yu, Biao ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

[2] Jiangsu Kanion Pharmaceut Co, Jiangsu 222001, Peoples R China

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 06期

关键词：

Dioscorea septemloba; Dioscoreaceae; cholestane glycoside; spirostane glycoside; steroid;

D O I：

10.1016/j.phytochem.2007.12.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cholestane glycosides, dioseptemlo sides A (1) and B (2), together with six spirostane glycosides, dioseptemlo sides C-H (3-8), were isolated from the rhizomes of Dioscorea septemloba. Their structures were established on the basis of physical data, spectroscopic analysis (HRESIMS, ID and 2D NMR), and chemical methods. Spirostane aglcones containing hydroxyl group at C-7, as found in compounds 4-7, were reported in the family Dioscoreaccae for the first time. These compounds did not show considerable inhibitory anti-tumor activities at a concentration of 10 mu M. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1411 / 1418

页数：8

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