Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer

被引：260

作者：

Sun, Yao ^{[1
,2
]}

Qu, Chunrong ^{[1
,2
]}

Chen, Hao ^{[3
,4
]}

He, Maomao ^{[1
,2
]}

Tang, Chu ^{[3
,4
]}

Shou, Kangquan ^{[3
,4
]}

Hong, Suhyun ^{[3
,4
]}

Yang, Meng ^{[5
]}

Jiang, Yuxin ^{[5
]}

Ding, Bingbing ^{[1
,2
]}

Xiao, Yuling ^{[1
,2
]}

Xing, Lei ^{[3
,4
]}

Hong, Xuechuan ^{[1
,2
]}

Cheng, Zhen ^{[3
,4
]}

机构：

[1] Wuhan Univ, State Key Lab Virol, Key Lab Combinatorial Biosynth & Drug Discovery M, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China

[2] Wuhan Univ, Hubei Prov Key Lab Dev Originated Dis, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China

[3] Stanford Univ, BioX Program, MIPS, Canary Ctr Stanford Canc Early Detect, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Radiol, Canary Ctr Stanford Canc Early Detect, Stanford, CA 94305 USA

[5] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Ultrasound, Beijing, Peoples R China

来源：

CHEMICAL SCIENCE | 2016年 / 7卷 / 09期

关键词：

NEAR-INFRARED WINDOW; PROSTATE-CANCER; FLUORESCENCE; PROBES; EMISSION; PLATFORM;

D O I：

10.1039/c6sc01561a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Optical imaging of diseases represents a highly dynamic and multidisciplinary research area, and second near-infrared window (NIR-II, 1000-1700 nm) imaging is at the forefront of the research on optical imaging techniques. Small-molecule based NIR-II (1000-1700 nm) dyes are highly promising candidates for in vivo molecular imaging because of their high biocompatibility, fast excretion, and high clinical translation ability. However, research reports on small-molecule based NIR-II dyes and probes are rare. Herein, we designed a series of fluorescent compounds (Q1, Q2, Q3, and Q4) and investigated the relationships between their structures and absorption/fluorescence properties. Q4 (maximum emission at 1100 nm) stood out as the dye with the best physical properties and thus was selected as a scaffold for the facile construction of two types of water-soluble and biocompatible NIR-II probes (Q4NPs and SCH1100). Highly specific gastrin-releasing peptide receptor (GRPR) targeted NIR-II imaging of prostate cancer in living mice was achieved using the small-molecule probe SCH1100, which represents the first small peptide based NIR-II probe for targeted cancer imaging. The attractive imaging properties of Q4-based NIR-II probes open up many opportunities for molecular imaging and clinical translation in the unique NIR-II window.

引用

页码：6203 / 6207

页数：5

共 28 条

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