Early Response Assessment to Targeted Therapy Using 3′-deoxy-3′[(18)F]-Fluorothymidine (18F-FLT) PET/CT in Lung Cancer

被引：14

作者：

Kairemo, Kalevi ^{[1
]}

Santos, Elmer B. ^{[1
]}

Macapinlac, Homer A. ^{[1
]}

Subbiah, Vivek ^{[2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Nucl Med, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Invest Canc Therapeut, Houston, TX 77030 USA

来源：

DIAGNOSTICS | 2020年 / 10卷 / 01期

关键词：

F-18-FLT; F-18-FLT PET; CT; lung cancer; response to therapy; small cell lung cancer; non-small cell lung cancer; POSITRON-EMISSION-TOMOGRAPHY; PULMONARY-LESIONS; FDG-PET; FLT-PET; PROLIFERATION; PERFORMANCE;

D O I：

10.3390/diagnostics10010026

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography/computed tomography (F-18-FDG PET/CT) is a sensitive nuclear medicine modality, specificity for characterizing lung cancer is limited. Tumor proliferation and early response to molecularly targeted therapy could be visualized using 3 '-deoxy-3 '[(18)F]-fluorothymidine (F-18-FLT) PET/CT. The superiority of F-18-FLT PET/CT over F-18-FDG PET/CT in early therapeutic monitoring has been well described in patients after chemotherapy, radiotherapy, and/or chemo/radiotherapy. In thispilot study, we explorethe use of F-18-FLT PET/CT as an early response evaluation modality in patients with lung cancerand provide specific case studies of patients with small cell lung cancer and non-small cell lung cancer who received novel targeted therapies. Early response for c-MET inhibitor was observed in four weeks and for MDM2 inhibitor in nine days.

引用

页数：7

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