Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity

被引：3

作者：

Jang, Jun-Pil ^{[1
]}

Kwon, Min Cheol ^{[1
,2
]}

Nogawa, Toshihiko ^{[3
]}

Takahashi, Shunji ^{[4
,5
]}

Osada, Hiroyuki ^{[3
]}

Ahn, Jong Seog ^{[1
,2
]}

Ko, Sung-Kyun ^{[1
,2
]}

Jang, Jae-Hyuk ^{[1
,2
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol KRIBB, Anticanc Agent Res Ctr, Cheongju 28116, South Korea

[2] Univ Sci & Technol UST, KRIBB Sch Biosci, Dept Biomol Sci, Daejeon 34141, South Korea

[3] RIKEN, Ctr Sustainable Res Sci, 2-1 Hirosawa, Wako, Saitama 3510198, Japan

[4] RIKEN, Ctr Sustainable Res Sci, Nat Prod Biosynth Res Unit, 2-1 Hirosawa, Wako, Saitama 3510198, Japan

[5] RIKEN, RIKEN KRIBB Joint Res Unit, 2-1 Hirosawa, Wako, Saitama 3510198, Japan

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2021年 / 31卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

Thiolactomide; Streptomyces sp; N-acetyl homocysteine thiolactone; neuroprotective activity; 6-hydroxydopamine; OXIDATIVE STRESS;

D O I：

10.4014/jmb.2108.08015

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new homocysteine thiolactone derivative, thiolactomide (1), was isolated along with a known compound, N-acetyl homocysteine thiolactone (2), from a culture extract of soil-derived Streptomyces sp. RK88-1441. The structures of these compounds were elucidated by detailed NMR and MS spectroscopic analyses with literature study. In addition, biological evaluation studies revealed that compounds 1 and 2 both exert neuroprotective activity against 6-hydroxydopamine (6-OHDA)-mediated neurotoxicity by blocking the generation of hydrogen peroxide in neuroblastoma SH-SY5Y cells.

引用

页码：1667 / 1671

页数：5

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