Circulating RNA in Blood Plasma as a Diagnostic Marker of Breast Cancer

被引：0
作者：
Turchaninova, M. A. [1 ]
Mesheryakov, A. A. [2 ]
Rakhmankulova, Z. P. [2 ]
Rebrikov, D. V. [1 ,3 ]
机构：
[1] CJC DNA Technol, Moscow 115478, Russia
[2] Russian Acad Med Sci, Blokhin Russian Canc Res Ctr, Moscow 109801, Russia
[3] Vavilov Inst Gen Genet, Moscow, Russia
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2011年 / 37卷 / 03期
关键词：
extracellular RNA; breast cancer; cytokines; PCR; MESSENGER-RNA; SERUM; CYTOKINES; PROGNOSIS; TIME; TOOL;
D O I：
10.1134/S1068162011030186
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The representation patterns of RNA of 15 cytokines were analyzed in blood cells and blood plasma of patients with breast cancer and seemingly healthy women. The relative amount of IL-8 and IL-18 RNA in the plasma of breast cancer patients significantly increased as compared with the control group. At the same time, no obvious differences were found in the relative concentrations of these transcripts in blood cells of patients and control groups. The relative concentration of IL-8 RNA was higher in blood plasma of patients with locally advanced disease compared with early breast cancer patients.
引用
收藏
页码：351 / 355
页数：5
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