Anaphylactic bronchospasm during general anesthesia is not related to asthma

被引：11

作者：

Gouel-Cheron, A. ^{[1
]}

Neukirch, C. ^{[2
]}

Aubier, B. ^{[1
]}

Montravers, P. ^{[1
]}

Nicaise, P. ^{[3
]}

Chollet-Martin, S. ^{[3
]}

Mertes, P. -M. ^{[4
]}

Aubier, M. ^{[2
]}

Longrois, D. ^{[1
]}

机构：

[1] Hop Bichat Claude Bernard, Dept Anesthesie Reanimat, F-75877 Paris 18, France

[2] Hop Bichat Claude Bernard, Serv Pneumol, F-75877 Paris 18, France

[3] Hop Bichat Claude Bernard, Lab Immunol Autoimmun & Hypersensibilites, F-75877 Paris 18, France

[4] CHU Strasbourg, Nouvel Hop Civil, Serv Anesthesie Reanimat, F-67000 Strasbourg, France

来源：

ALLERGY | 2015年 / 70卷 / 04期

关键词：

anaphylaxis; asthma; atopy; bronchospasm; general anesthesia; HYPERSENSITIVITY REACTIONS; RAPACURONIUM; ALLERGY;

D O I：

10.1111/all.12565

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

In the general population, a history of asthma (HA) is associated with a higher risk of mortality of anaphylactic shock (AS), but it is unknown whether this association remains valid for intra-operative AS. The goal of this retrospective study was to investigate whether a HA was associated with a higher risk of bronchospasm during intra-operative AS. We analyzed 106 patients (January 2009 December 2012) with intra-operative AS: 57% of them had a confirmed IgE-mediated reaction and 27% had a HA. On logistic regression, the only factor statistically associated with bronchospasm was a neuromuscular blocking drug, with both IgE- or non-IgE-mediated reactions. These results suggest that the mechanisms of bronchospasm in AS may be different from those of asthma and that, in the presence of bronchospasm during anesthesia, AS should be considered to be the most likely cause.

引用

页码：453 / 456

页数：4

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