The ketogenic diet: One decade later

被引:256
作者
Freeman, John M. [1 ]
Kossoff, Eric H. [1 ]
Hartman, Adam L. [1 ]
机构
[1] Johns Hopkins Med Inst, John M Freeman Pediat Epilepsy Ctr, Dept Neurol, Baltimore, MD 21287 USA
关键词
ketogenic diet; pediatric epilepsy; mechanisms of action;
D O I
10.1542/peds.2006-2447
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The ketogenic diet, a high fat, adequate protein, low carbohydrate diet, has, during the past decade, had a resurgence of interest for the treatment of difficult- tocontrol seizures in children. This review traces its history, reviews its uses and side effects, and discusses possible alternatives and the diet's possible mechanisms of action. Finally, this review looks toward possible future uses of the ketogenic diet for conditions other than epilepsy.
引用
收藏
页码:535 / 543
页数:9
相关论文
共 94 条
[1]  
ABRAHAMS J, 2000, INTRO KETOGENIC DIET
[2]   ANIMAL-MODEL FOR KETOGENIC DIET - ELECTROCONVULSIVE THRESHOLD AND BIOCHEMICAL ALTERATIONS CONSEQUENT UPON A HIGH-FAT DIET [J].
APPLETON, DB ;
DEVIVO, DC .
EPILEPSIA, 1974, 15 (02) :211-227
[3]   Fasting versus gradual initiation of the ketogenic diet: A prospective, randomized clinical trial of efficacy [J].
Bergqvist, AGC ;
Schall, JI ;
Gallagher, PR ;
Cnaan, A ;
Stallings, VA .
EPILEPSIA, 2005, 46 (11) :1810-1819
[4]  
Bertoli Simona, 2002, Recenti Progressi in Medicina, V93, P671
[5]   A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat [J].
Bough, KJ ;
Eagles, DA .
EPILEPSIA, 1999, 40 (02) :138-143
[6]   Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet [J].
Bough, Kristopher J. ;
Wetherington, Jonathon ;
Hassel, Bjornar ;
Pare, Jean Francois ;
Gawryluk, Jeremy W. ;
Greene, James G. ;
Shaw, Renee ;
Smith, Yoland ;
Geiger, Jonathan D. ;
Dingledine, Raymond J. .
ANNALS OF NEUROLOGY, 2006, 60 (02) :223-235
[7]   Ketogenic diet in patients with Dravet syndrome [J].
Caraballo, RH ;
Cersósimo, RO ;
Sakr, D ;
Cresta, A ;
Escobal, N ;
Fejerman, N .
EPILEPSIA, 2005, 46 (09) :1539-1544
[8]  
Caraballo RH, 2006, EPILEPTIC DISORD, V8, P151
[9]   A pilot study of a ketogenic diet in patients with Lafora body disease [J].
Cardinali, Simonetta ;
Canafoglia, Laura ;
Bertoli, Simona ;
Franceschetti, Silvana ;
Lanzi, Giovanni ;
Tagliabue, Anna ;
Veggiotti, Pierangelo .
EPILEPSY RESEARCH, 2006, 69 (02) :129-134
[10]  
Conklin H. W., 1922, J Am Osteopath Assoc, V26, P11