Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea

被引:49
作者
Hanif, Novriyandi
Tanaka, Junichi [1 ]
Setiawan, Andi
Trianto, Agus
de Voogd, Nicole J.
Murni, Anggia
Tanaka, Chiaki
Higa, Tatsuo
机构
[1] Univ Ryukyus, Dept Chem Biol & Marine Sci, Okinawa 9030213, Japan
[2] Lampung Univ, Dept Chem, Bandar Lampung 35145, Indonesia
[3] Diponegoro Univ, Dept Marine Sci, Semarang 50234, Indonesia
[4] Natl Museum Nat Hist, NL-2300 RA Leiden, Netherlands
来源
JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 03期
关键词
D O I
10.1021/np0605081
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Four new (1-4) and 10 known polybrominated diphenyl ethers (5-11) have been isolated from the title sponge. The structures of the new entities were elucidated by interpretation of spectroscopic data and chemical transformations. These metabolites showed potent antimicrobial activity against Bacillus subtilis and moderate/weak cytotoxicity against NBT-T2 rat bladder epithelial cells. The major constituent 14 was treated under debromination conditions to give eight derivatives, which were subjected to a structure-activity relationship study. The results indicated that the presence of two phenolic hydroxyl groups and bromines at C-2 and/or C-5, as in 2, is important for the exhibition of antibacterial activity.
引用
收藏
页码:432 / 435
页数:4
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