Induction of protection against porcine cysticercosis in growing pigs by DNA vaccination

被引：22

作者：

Guo, Aijiang ^{[1
]}

Jin, Zhizhong ^{[1
]}

Zheng, Yadong ^{[1
]}

Hai, Gang ^{[1
]}

Yuan, Gailing ^{[1
]}

Li, Hailong ^{[1
]}

Cai, Xuepeng ^{[1
]}

机构：

[1] CAAS, Key Lab Vet Parasitol Gansu Prov, State Key Lab Vet Etiol Biol, Lanzhou Vet Res Inst, Lanzhou 730046, Gansu, Peoples R China

来源：

VACCINE | 2007年 / 25卷 / 01期

关键词：

Taenia solium; B antigen; protection;

D O I：

10.1016/j.vaccine.2006.03.073

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A DNA vaccine, pcDNA3-B, was developed by using the nucleotide sequence of Taenia solium B antigen and cloning into pcDNA3.1 plasmid. The growing pigs were vaccinated by one intramuscular infection of 200 or 1000 mu g pcDNA3-B. The immunization with 1000 mu g of pcDNA3-B showed 92.6% protection when the pigs were challenged by T. solium eggs and four of the five pigs vaccinated had no viable cysts. The results provide encouraging information on the use of pcDNA3-B vaccination for the prevention of cysticercosis. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：170 / 175

页数：6

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