Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery

被引：16

作者：

Cosma, Stefano ^{[1
]}

Carosso, Andrea Roberto ^{[1
]}

Corcione, Silvia ^{[2
,3
]}

Cusato, Jessica ^{[4
]}

Borella, Fulvio ^{[1
]}

Antonucci, Miriam ^{[4
]}

Marozio, Luca ^{[1
]}

Revelli, Alberto ^{[1
]}

Preti, Mario ^{[1
]}

Ghisetti, Valeria ^{[5
]}

Di Perri, Giovanni ^{[6
]}

Benedetto, Chiara ^{[1
]}

机构：

[1] Univ Turin, Dept Surg Sci, City Hlth & Sci, Gynecol & Obstet 1, Turin, Italy

[2] Univ Turin, Dept Med Sci, Infect Dis, Turin, Italy

[3] Tufts Univ, Sch Med, Boston, MA 02111 USA

[4] Univ Turin, Amedeo Savoia Hosp, Dept Med Sci, Lab Clin Pharmacol & Pharmacogenet, Turin, Italy

[5] ASL Citta Torino, Amedeo Savoia Hosp, Lab Microbiol & Virol, Turin, Italy

[6] Univ Turin, Amedeo Savoia Hosp, Dept Med Sci, Unit Infect Dis, Turin, Italy

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2021年 / 144卷

关键词：

SARS-CoV-2; Pregnancy; Antibodies; COVID-19; immunology; vaccines;

D O I：

10.1016/j.jri.2021.103285

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report herein the longest-lasting study of SARS-CoV-2 antibody profile in pregnancy, from first trimester infection to delivery. Seventeen out of 164 pregnant women tested positive for COVID-19. Throughout pregnancy, the neutralizing antibody titer remained stable, whilst a significant decline in the non-neutralizing antibodies was observed after 16 weeks of gestation. All the newborns of women who developed IgG antibodies showed the presence of the same antibodies in arterial cord blood. Knowledge on the longevity and type of SARSCoV-2 antibody response may help to guide vaccination strategies in pregnancy.

引用

页数：3

共 50 条

[1] The pregnancy outcomes of women with SARS-CoV-2 infection in the first trimester ---a longitudinal cohort study
Hu, Jiangtao
Li, Ju
Lin, Li
Li, Zhi
Wang, Jing
BMC PREGNANCY AND CHILDBIRTH, 2025, 25 (01)
[2] SARS-Cov-2 in first trimester pregnancy: a cohort study
Freiesleben, N. la Cour
Egerup, P.
Hviid, K. V. R.
Severinsen, E. R.
Kolte, A. M.
Westergaard, D.
Olsen, L. Fich
Praetorius, L.
Zedeler, A.
Christiansen, A-M H.
Nielsen, J. R.
Bang, D.
Berntsen, S.
Olle-Lopez, J.
Ingham, A.
Bello-Rodriguez, J.
Storm, D. M.
Ethelberg-Findsen, J.
Hoffmann, E. R.
Wilken-Jensen, C.
Jorgensen, F. S.
Westh, H.
Jorgensen, H. L.
Nielsen, H. S.
HUMAN REPRODUCTION, 2021, 36 (01) : 40 - 47
[3] Impact of SARS-CoV-2 infection during pregnancy and persistence of antibody response
Zelini, Paola
Perotti, Francesca
Scatigno, Annachiara Licia
Dominoni, Mattia
Zavaglio, Federica
Arossa, Alessia
Piccini, Stefania
Angelini, Micol
Ghirardello, Stefano
Lilleri, Daniele
Baldanti, Fausto
Spinillo, Arsenio
NEW MICROBIOLOGICA, 2022, 45 (03) : 181 - 189
[4] First- or second-trimester SARS-CoV-2 infection and subsequent pregnancy outcomes
Hughes, Brenna L.
Sandoval, Grecio J.
Metz, Torri D.
Clifton, Rebecca G.
Grobman, William A.
Saade, George R.
Manuck, Tracy A.
Longo, Monica
Sowles, Amber
Clark, Kelly
Simhan, Hyagriv N.
Rouse, Dwight J.
Mendez-Figueroa, Hector
Gyamfi-Bannerman, Cynthia
Bailit, Jennifer
Costantine, Maged M.
Sehdev, Harish M.
Tita, Alan T. N.
Macones, George A.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2023, 228 (02) : 226.e1 - 226.e9
[5] The Antibody Response to SARS-CoV-2 Infection
Hueston, Linda
Kok, Jen
Guibone, Ayla
McDonald, Damien
Hone, George
Goodwin, James
Carter, Ian
Basile, Kerri
Sandaradura, Indy
Maddocks, Susan
Sintchenko, Vitali
Gilroy, Nicole
Chen, Sharon
Dwyer, Dominic E.
O'Sullivan, Matthew V. N.
OPEN FORUM INFECTIOUS DISEASES, 2020, 7 (09):
[6] Longitudinal Analysis of Antibody Response Following SARS-CoV-2 Infection Depending on Disease Severity: A Prospective Cohort Study
Zirou, Christina
Gumeni, Sentiljana
Bellos, Ioannis
Ntanasis-Stathopoulos, Ioannis
Sklirou, Aimilia D.
Bagratuni, Tina
Korompoki, Eleni
Apostolakou, Filia
Papassotiriou, Ioannis
Trougakos, Ioannis P.
Terpos, Evangelos
VIRUSES-BASEL, 2023, 15 (11):
[7] SARS-CoV-2 antibody response following COVID-19 vaccination, a longitudinal study
Chavhan, Smita Santosh
Dhikale, Prasad Tukaram
Adsul, Balkrishna B.
Gokhale, Chinmay N.
Ingale, Aniket R.
Pawar, Pradnya N.
Jadhav, Nilam
INDIAN JOURNAL OF COMMUNITY MEDICINE, 2023, 48 (04) : 539 - 543
[8] Trimester and severity of SARS-CoV-2 infection during pregnancy and risk of hypertensive disorders in pregnancy
Parker, Samantha E.
Annapragada, Bhavana
Chestnut, Idalis A.
Fuchs, Jessica
Lee, Annette
Sabharwal, Vishakha
Wachman, Elisha M.
Yarrington, Christina D.
HYPERTENSION IN PREGNANCY, 2024, 43 (01)
[9] Obstetric and neonatal outcomes after SARS-CoV-2 infection in the first trimester of pregnancy: A prospective comparative study
Cosma, Stefano
Carosso, Andrea Roberto
Cusato, Jessica
Borella, Fulvio
Bertero, Luca
Bovetti, Marialuisa
Bevilacqua, Federica
Mengozzi, Giulio
Mazzone, Raffaela
Ghisetti, Valeria
Di Perri, Giovanni
Benedetto, Chiara
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2022, 48 (02) : 393 - 401
[10] SARS-COV-2 IgG antibody response in pregnant women at delivery
Tsatsaris, Vassilis
Mariaggi, Alice-Andree
Launay, Odile
Couffignal, Camille
Rousseau, Jessica
Ancel, Pierre Yves
Marcault, Estelle
Ville, Yves
Cordier, Anne-Gael
Vivanti, Alexandre
Carrara, Julie
Luton, Dominique
Dommergues, Marc
Borie, Constance
Kayem, Gilles
Alessandrini, Vivien
Lecomte, Laurence
Meritet, Jean Francois
Leruez-Ville, Marianne
Goffinet, Francois
Dubois, Claire
Picone, Olivier
Fellous, Christelle Vauloup
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION, 2021, 50 (07)

← 1 2 3 4 5 →