Novel human histamine H3 receptor antagonists

被引：42

作者：

Shah, C ^{[1
]}

McAtee, L ^{[1
]}

Breitenbucher, JG ^{[1
]}

Rudolph, D ^{[1
]}

Li, XB ^{[1
]}

Lovenberg, TW ^{[1
]}

Mazur, C ^{[1
]}

Wilson, SJ ^{[1
]}

Carruthers, NI ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, San Diego, CA 92121 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(02)00738-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

High throughput screening, using the recombinant human H-3 receptor, was used to identify novel histamine H-3 receptor antagonists. Evaluation of the lead compounds ultimately afforded potent, selective, orally bioavailable compounds (e.g., 38) with favorable blood-brain barrier penetration. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3309 / 3312

页数：4

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