Experimental and computational studies of determinants of membrane-protein folding

被引：26
|
作者：
Liang, J [1 ]
机构：
[1] Univ Illinois, Dept Bioengn, Chicago, IL 60607 USA
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 06期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/S1367-5931(02)00393-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent experiments and analysis have demonstrated the important roles of hydrogen bonding and polar-polar interactions in driving transmembrane helix-helix association. Further details of the energetics of helix-helix association and interhelical packing geometry are being mapped out. Many sequence motifs and a few spatial motifs promoting helical associations have also been identified.
引用
收藏
页码：878 / 884
页数：7
相关论文
共 50 条
  • [1] THE FOLDING OF A MEMBRANE-PROTEIN - BACTERIORHODOPSIN
    ENGELMAN, DM
    FEDERATION PROCEEDINGS, 1986, 45 (06) : 1592 - 1592
  • [2] DETERMINANTS OF MEMBRANE-PROTEIN TOPOLOGY
    BOYD, D
    MANOIL, C
    BECKWITH, J
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (23) : 8525 - 8529
  • [3] INTERMEDIATES IN THE FOLDING OF THE MEMBRANE-PROTEIN BACTERIORHODOPSIN
    BOOTH, PJ
    FLITSCH, SL
    STERN, LJ
    GREENHALGH, DA
    KIM, PS
    KHORANA, HG
    NATURE STRUCTURAL BIOLOGY, 1995, 2 (02): : 139 - 143
  • [4] BACTERIORHODOPSIN STRUCTURE AND MEMBRANE-PROTEIN FOLDING MOTIFS
    WALLACE, BA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1983, 186 (AUG): : 156 - PHYS
  • [5] A BIOPHYSICAL STUDY OF INTEGRAL MEMBRANE-PROTEIN FOLDING
    HUNT, JF
    BOUSCHE, O
    KALGHATGI, K
    REILLY, K
    HORVATH, C
    ROTHSCHILD, KJ
    ENGELMAN, DM
    BIOPHYSICAL JOURNAL, 1993, 64 (02) : A124 - A124
  • [6] AN FTIR STUDY OF INTEGRAL MEMBRANE-PROTEIN FOLDING
    HUNT, JF
    EARNEST, TN
    ENGELMAN, DM
    ROTHSCHILD, KJ
    BIOPHYSICAL JOURNAL, 1988, 53 (02) : A97 - A97
  • [7] THE STRUCTURE OF A STABLE MEMBRANE-PROTEIN FOLDING INTERMEDIATE
    HUNT, JF
    EARNEST, TN
    ROTHSCHILD, KJ
    ENGELMAN, DM
    BIOPHYSICAL JOURNAL, 1987, 51 (02) : A452 - A452
  • [8] Computational studies of protein folding
    Skolnick, J
    Kolinski, A
    COMPUTING IN SCIENCE & ENGINEERING, 2001, 3 (05) : 40 - 50
  • [9] Computational studies of protein folding
    Friesner, RA
    Gunn, JR
    ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1996, 25 : 315 - 342
  • [10] Computational studies of protein folding
    Skolnick, J.
    Kolinski, A.
    Computing in Science and Engineering, 2001, 3 (05):
12345