Experimental inoculation of calves with laboratory strains of bovine viral diarrhea virus

被引：12
|
作者：
Polak, MP [1 ]
Zmudzinski, JF [1 ]
机构：
[1] Natl Inst Vet Res, Dept Virol, PL-24100 Pulawy, Poland
来源：
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 2000年 / 23卷 / 03期
关键词：
bovine viral diarrhea virus; experimental inoculation; pathogenesis; laboratory strains; clinical course; leukopenia;
D O I：
10.1016/S0147-9571(99)00060-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Diarrhea, erosions and ulcers of the oral mucosa, with conjunctival and nasal discharges, were observed in six calves inoculated with a mixture of two laboratory cytopathic reference strains of bovine viral diarrhea virus (BVDV)-Oregon C24 V and NADL. The clinical picture was accompanied by biphasic body temperature elevation, transient leukopenia and a decrease in the number of lymphocytes. High dose of viruses and multiple routes of inoculation promoted the development of clinical and hematological changes typical for BVDV infection although laboratory strains were used. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：141 / 151
页数：11
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